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| Product Name | Phospho-FLT3- Y589/591 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | DB |
| DB~~1:500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 112903 Da |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG ａnd regulates differentiation, proliferation ａnd survival of hemaoietic progenitor cells ａnd of dendritic cells. Promotes phosphorylation of SHC1 ａnd AKT1, ａnd activation of the downstream effector MTOR. Promotes activation of RAS signaling ａnd phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, ａnd STAT5A and/or STAT5B Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation ａnd resistance to apoptosis via the activation of multiple signaling pathways More |
| Tissue Specificity | Detected in bone marrow, in hemaoietic stem cells, in myeloid progenitor cells ａnd in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen ａnd lymph node, ａnd at low levels in kidney ａnd pancreas. Highly expressed in T-cell leukemia |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface ａnd a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation |
| Entrez Gene | 2322 |
|---|
Dot blot analysis of anti-Phospho-FLT3 (Tyr589/591) Antibody Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
| Application Notes | DB~~1:500: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
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