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| Product Name | Flt3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB~~1:100~500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 112640 Da |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG ａnd regulates differentiation, proliferation ａnd survival of hemaoietic progenitor cells ａnd of dendritic cells. Promotes phosphorylation of SHC1 ａnd AKT1, ａnd activation of the downstream effector MTOR. Promotes activation of RAS signaling ａnd phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, ａnd STAT5A and/or STAT5B Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation ａnd resistance to apoptosis via the activation of multiple signaling pathways More |
| Tissue Specificity | Hemaoietic stem ａnd progenitor cell- enriched populations. Found in brain, placenta ａnd testis |
| Cellular Localization | Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen (By similarity) Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface ａnd a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity) |
| Entrez Gene | 14255 |
|---|---|
| Nucleotide Accession | NP_034359.2 |
Mouse Flt3 Antibody (N-term) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Flt3 antibody detected the Flt3 protein (arrow).
| Application Notes | WB~~1:100~500: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
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