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| Product Name | Anti-ITGB4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHCWB |
| WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ITGB4 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | integrin subunit beta 4 |
| Gene Summary | ntegrins are heterodimers comprised of alpha ａnd beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha ａnd beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, ａnd transduced signals that regulate gene expression ａnd cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit ａnd is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] More |
| Molecular Weight(MW) | 202KD,107KD |
| Cellular Localization | Plasma membrane |
Western blot analysis using ITGB4 antibody against Cos7(1), Hela(2), Hek293(3), A431(4) cell lysate.
Immunohistochemical analysis of paraffin-em
Immunofluorescence analysis of Hela cells using ITGB4 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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