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您的位置：首页 > 技术文献 > 产品说明 > GRP78 BiP [2-7] Catalog Number：OM638616

标题GRP78 BiP [2-7] Catalog Number：OM638616

提供者：上海笃玛生物科技有限公司发布时间：2024/8/30 阅读次数：10次 >>进入该公司展台

Product Profile

Product Name	GRP78 BiP [2-7]
Antibody Type	Primary Antibodies
Product description	Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, ａnd maintains them in a state competent for subsequent folding ａnd oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress ａnd heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory ａnd pro-resolutory signals into immune networks, thus helping to resolve inflammation. More
Immunogen	peptide

Key Feature

Clonality	Monoclonal
Isotype	IgG1
Host Species	Mouse
Tested Applications	WBICCIHC
	WB:1:5,000-1:10,000 ICC:1:200
Species Reactivity	Human
Concentration	2 mg/mL.

Target Information

Alternative Names	78 kDa glucose regulated protein antibody 78 kDa glucose-regulated protein antibody AL022860 antibody AU019543 antibody BIP antibody D2Wsu141e antibody D2Wsu17e antibody Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody Epididymis secretory sperm binding protein Li 89n antibody FLJ26106 antibody Glucose Regulated Protein 78kDa antibody GRP 78 antibody GRP-78 antibody GRP78 antibody GRP78_HUMAN antibody Heat shock 70 kDa protein 5 antibody Heat Shock 70kDa Protein 5 antibody Heat shock protein family A (Hsp70) member 5 antibody HEL S 89n antibody Hsce70 antibody HSPA 5 antibody HSPA5 antibody Immunoglobulin Heavy Chain Binding Protein antibody Immunoglobulin heavy chain-binding protein antibody mBiP antibody MIF2 antibody Sez7 antibody More
Molecular Weight(MW)	78kDa
Cellular Localization	Cylasm, endoplasmic reticulum lumen

Database Links

SwissProt ID	P11021

Application

Application

Fig1: Western blot analysis on human spermatozoa lysates using anti- GRP78 mouse mAb.
Application

Fig2: ICC staining GRP78 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Application

Fig3: Western blot analysis of GRP78 on hybrid fish (crucian-carp) heart tissue lysate using anti-GRP78 antibody at 1/500 dilution.

Positive Control	Hela, human spermatozoa
Application Notes	WB:1:5,000-1:10,000 ICC:1:200

Additional Information

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

关键词：稳定性强特异性强灵敏度高

上一篇：PDB-PT747-6824 电源分配板 4个8P超微W580-G20曙光服务器电源背板下一篇：GRP78 Catalog Number：OM631100

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