标题DKK3 Antibody (N-term) Catalog Number：OM231334

提供者：上海笃玛生物科技有限公司发布时间：2024/9/4 阅读次数：6次 >>进入该公司展台

Product Name	DKK3 Antibody (N-term)
Antibody Type	Primary Antibodies

Gene Synonyms	REIC
Alternative Names	DKK3 REIC Dickkopf-related protein 3
Molecular Weight(MW)	38390 Da
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt ａnd by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis ａnd eye formation. In the adult, Dkks are implicated in bone formation ａnd bone disease, cancer ａnd Alzheimer disease (By similarity) More
Tissue Specificity	Highest expression in heart, brain, ａnd spinal cord
Cellular Localization	Secreted.

Entrez Gene	27122
Nucleotide Accession	NP_037385

Application

Formalin-fixed ａnd paraffin-embedded human brain tissue reacted with DKK3 antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application

Formalin-fixed ａnd paraffin-embedded human breast carcinoma tissue reacted with DKK3 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Application

DKK3 Antibody (A30) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the DKK3 antibody detected the DKK3 protein (arrow).

Application Notes	IHC~~1:50~100 WB~~1:100~500:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high ａnd low pH buffers ａnd neutralized immediately, followed by dialysis against PBS.

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