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| Product Name | DKK3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 4G7 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB~~1:500 - 2000. FC~~1:200 - 400.: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | |
| Molecular Weight(MW) | 38390 Da |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt ａnd by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis ａnd eye formation. In the adult, Dkks are implicated in bone formation ａnd bone disease, cancer ａnd Alzheimer disease (By similarity) More |
| Tissue Specificity | Highest expression in heart, brain, ａnd spinal cord |
| Cellular Localization | Secreted. |
| Entrez Gene | 27122 |
|---|---|
| Nucleotide Accession | NP_056965.3 |
Figure 1: Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) ａnd HL7702 (3) cell lysate.
Figure 2: Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) ａnd negative control (purple).
| Application Notes | WB~~1:500 - 2000. FC~~1:200 - 400.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human DKK3 expressed in E. Coli. |
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