标题CD59 antibody Catalog Number：OM245695

提供者：上海笃玛生物科技有限公司发布时间：2024/9/4 阅读次数：21次 >>进入该公司展台

Product Name	CD59 antibody
Antibody Type	Primary Antibodies
Product description	Mouse Monoclonal Antibody [8D2B8] to CD59This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, ａnd it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia ａnd thrombosis, ａnd which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] More
Immunogen	The immunogen corresponding to a region within amino acids 31 ａnd 111 of human CD59 expressed in E. Coli.

Clonality	Monoclonal
Isotype	IgG1
Clone Number	8D2B8
Host Species	Mouse
Tested Applications	ELISAFACSICC/IFIHCIHC-PWB
	ELISA: 1/10000.:
Species Reactivity	Human
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification

Gene Synonyms	EJ16 16.3A5 MIC11 HRF20 MIN1 MSK21 MAC-IP HRF-20 MIRL G344 MACIF EJ30 P18-20 MIN3 MIN2 EL3 More
Target	CD59
Molecular Weight(MW)	14.2 kDa (note)

Application

ELISA analysis of control antigen ａnd antigen using CD59 antibody [8D2B8].
Application

WB analysis of human CD59 recombinant protein using CD59 antibody [8D2B8].
Application

WB analysis of lysates from (1) untransfected ａnd (2) CD59 (a.a. 31-111)-hIgGFc transfected HEK293 cells using CD59 antibody [8D2B8].
Application

IHC-P analysis of bladder cancer tissues using CD59 antibody [8D2B8].
Application

IHC-P analysis of esophageal cancer tissues using CD59 antibody [8D2B8].
Application

ICC/IF analysis of MCF-7 cells using CD59 antibody [8D2B8] (green), Alexa Fluor-555 phalloidin (red) ａnd DRAQ5 fluorescent DNA dye (blue).
Application

FACS analysis of HeLa cells using CD59 antibody [8D2B8] (green) or a negative control (red).
Application

ICC/IF analysis of HeLa cells using CD59 antibody [8D2B8] (green), Alexa Fluor-555 phalloidin (red) ａnd DRAQ5 fluorescent DNA dye (blue).

Application Notes	ELISA: 1/10000.:

Form	Liquid
Storage Instructions	4°C; -20°C for long term storage
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide ａnd 0.5% protein stabilizer.

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