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| Product Name | CD59 Antibody (H-85) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CD59 is a GPI-anchored glycoprotein that is expressed on leukocytes, vascular endothelial cells, various epithelial cells ａnd placenta. CD59 acts together with CD58 in mediating T cell adhesion ａnd activation, ａnd it may be a second ligand of CD2. CD59 functions as a regulator of the terminal pathway of complement by binding to the C8/C9 components of the assembling membrane attack complex (MAC) on host cell membranes, to s the formation of the lytic pore. CD59 also drives both calcium release ａnd activation of lipid-raft associated signalling molecules such as tyrosine kinases. CD59 gene has two p53-responsive domains that may be implicated in the defense of host cells from damage by the complement system in inflammation, suggesting that p53 could be used to mediate susceptibility of tumor cells to the complement lysis during chemotherapy. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of CD59 of human origin by WB, IP, IF, IHC(P) ａnd ELISA: | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | |
|---|---|
| Tissue Specificity | epie corresponding to amino acids 26-110 mapping within an internal region of CD59 of human origin |
| Entrez Gene | 966 |
|---|
Immunoperoxidase staining of formalin fixed, paraffin-embedded human urinary bladder tissue showing membrane ａnd cylasmic staining of urothelial cells.
Western blot analysis of CD59 expression in BJAB (A), ES-2 (B) ａnd Caki-1 (C) whole cell lysates.
| Application Notes | recommended for detection of CD59 of human origin by WB, IP, IF, IHC(P) ａnd ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
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