标题FOXP1 [JF1017] Catalog Number：OM628229

提供者：上海笃玛生物科技有限公司发布时间：2024/9/6 阅读次数：13次 >>进入该公司展台

Product Name	FOXP1 [JF1017]
Antibody Type	Primary Antibodies
Product description	The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 ａnd FOXP2 are expressed abundantly in the lung with lower levels of expression in neural, intestinal ａnd cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. The gene encoding human FOXP1 maps to chromosome 3p14.1. The gene encoding human FOXP2 maps to chromosome 7q31. The gene encoding FOXP3, a third member of this family, maps to chromosome Xp11.23-Xq13.3. Mutations in this gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein, also known as scurfin, is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T-cell activation. More
Immunogen	recombinant protein

Alternative Names	12CC4 antibody FLJ23741 antibody Fork head related protein like B antibody Forkhead box P1 antibody Forkhead box protein P1 antibody FOX P1 antibody FOXP 1 antibody foxp1 antibody FOXP1_HUMAN antibody Glutamine rich factor 1 antibody hFKH1B antibody HSPC215 antibody MGC12942 antibody MGC88572 antibody MGC99551 antibody QRF 1 antibody QRF1 antibody More
Molecular Weight(MW)	77/75 kDa
Cellular Localization	Nucleus.

SwissProt ID	Q9H334 P58462 Q498D1

Application

Fig1: Western blot analysis of FOXP1 on different lysates using anti-FOXP1 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: Jurkat Lane 3: MCF-7
Application

Fig2: Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-FOXP1 antibody. Counter stained with hematoxylin.
Application

Fig3: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-FOXP1 antibody. Counter stained with hematoxylin.
Application

Fig4: Flow cytometric analysis of MCF-7 cells with FOXP1 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody

Positive Control	Jurkat, MCF-7, Hela, human colon cancer tissue, human breast carcinoma tissue.
Application Notes	WB:1:1,000-1:5,000 FC:1:50-1:100 IHC:1:50-1:200

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

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