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| Product Name | Anti-VAV1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IF |
| ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | VAV1 |
|---|---|
| Gene Synonyms | |
| Gene Summary | vav guanine nucleotide exchange factor 1 |
| Target Description | This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements ａnd transcriptional alterations. The encoded protein is important in hemaoiesis, playing a role in T-cell ａnd B-cell development ａnd activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression ａnd binding of these partners initiates profound morphological changes, cytoskeletal rearrangements ａnd the JNK/SAPK signaling cascade, leading to increased levels of viral transcription ａnd replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012] |
| Molecular Weight(MW) | 98KD |
| Cellular Localization | Cytosol,Plasma Membrane |
Immunofluorescence analysis of Hela cells using VAV1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | ICC/IF:1:100-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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