标题VAV1 [C10-E11] Catalog Number：OM627766

提供者：上海笃玛生物科技有限公司发布时间：2024/9/9 阅读次数：21次 >>进入该公司展台

Product Name	VAV1 [C10-E11]
Antibody Type	Primary Antibodies
Product description	The Vav gene was originally identified on the basis of its oncogenic activation during the course of gene transfer assays. The major translational product of the Vav proto-oncogene has been identified as a protein containing an array of structural motifs. This protein, known as Vav, Vav1 or p95Vav, contains an N-terminal helix-loop-helix domain ａnd a leucine zipper motif similar to that of Myc family proteins that, if deleted, causes oncogenic activation. In addition, Vav contains an SH2 domain, which could indicate its role as a substrate for tyrosine kinases. Expression of Vav is limited exclusively to cells of hemaoietic origin, including those of the erythroid, lymphoid ａnd myeloid lineages. These results suggest that Vav may represent a new type of signal transduction molecule involved in the transduction of tyrosine phosphorylation signaling into transcriptional events. More
Immunogen	Recombinant protein

Alternative Names	Oncogene vav antibody p95Vav antibody Proto-oncogene vav antibody Protooncogene vav antibody VAV 1 antibody VAV 1 oncogene antibody VAV antibody Vav proto oncogene antibody VAV_HUMAN antibody VAV1 antibody
Molecular Weight(MW)	98 kDa
Cellular Localization	Cytosol.

SwissProt ID	P15498

Application

Fig1: Western blot analysis of VAV1 on Jurkat cell lysate using anti-VAV1 antibody at 1/1,000 dilution.
Application

Fig2: Western blot analysis of VAV1 on human VAV1 recombinant protein using anti-VAV1 antibody at 1/1,000 dilution.
Application

Fig3: Western blot analysis of VAV1 on HEK293 (1) ａnd VAV1-hIgGFc transfected HEK293 (2) cell lysate using anti-VAV1 antibody at 1/1,000 dilution.
Application

Fig4: Flow cytometric analysis of Hela cells with VAV1 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

Positive Control	Jurkat, human VAV1 recombinant protein, VAV1-hIgGFc transfected HEK293 cell lysate, Hela.
Application Notes	WB:1:500-1:1,000 FC:1:100-1:200

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

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