标题VAV1 Antibody Catalog Number：OM294843

The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hemaoiesis, playing a role in T-cell ａnd B-cell development ａnd activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression ａnd binding of these partners initiates profound morphological changes, cytoskeletal rearrangements ａnd the JNK/SAPK signaling cascade, leading to increased levels of viral transcription ａnd replication.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
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This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.

WB

Human