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| Product Name | INCENP Antibody (H-153) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The centromere proteins CENP-A, CENP-B, CENP-C, CENP-E, CENP-F (also designated mitosin), CENP-H ａnd INCENP are kinetochore proteins that are involved in mitotic events. The centromere proteins are expressed at different levels throughout the cell cycle ａnd are involved in the formation of the centromere ａnd the organization ａnd function of the kinetochore. INCENP, which also is designated inner centromere protein, is a chromosomal passenger protein that is crucial for chromosome segregation. During mitosis it is also required for cytokinesis onset. This protein, which can form a homodimer or a heterodimer, binds directly to microtubules ａnd interacts with AURKB, AURKC, CBX3 ａnd ∫ Tubulin. This nuclear protein localizes to the mitotic spindle, methaphase chromosomes ａnd during anaphase, to the equatorial cortex. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of INCENP of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including equine, bovine ａnd porcine: | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | |
|---|---|
| Tissue Specificity | epie corresponding to amino acids 771-923 mapping at the C-terminus of INCENP of human origin |
| Entrez Gene | 3619 |
|---|
Western blot analysis of INCENP expression in Jurkat whole cell lysate.
| Application Notes | recommended for detection of INCENP of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including equine, bovine ａnd porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
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