标题GluR2 (phospho Ser880) antibody Catalog Number：OM254730

提供者：上海笃玛生物科技有限公司发布时间：2024/9/11 阅读次数：12次 >>进入该公司展台

Product Name	GluR2 (phospho Ser880) antibody
Antibody Type	Primary Antibodies
Product description	Rabbit Polyclonal antibody to GluR2 (phospho Ser880)Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain ａnd are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), ａnd function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human ａnd animal studies suggest that pre-mRNA editing is essential for brain function, ａnd defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip ａnd flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008] More
Immunogen	KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human GLUR2 (pS880). The exact sequence is proprietary.

Gene Synonyms	GluR-K2 GLURB GluA2 HBGR2 GRIA2 GLUR2 glutamate receptor ionotropic AMPA 2 More
Target	GluR2
Tissue Specificity	Recognizes endogenous levels of GLUR2 (pS880) protein.

Application

Western blot analysis of GLUR2 (pS880) expression in mouse brain (A); rat brain (B) whole cell lysates.
Application

Immunohistochemical analysis of GLUR2 (pS880) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature ａnd detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin ａnd mounted with DPX.

Application Notes	WB: 1:500 - 1:1000. IHC-P: 1:100 - 1:200:

Form	Liquid
Storage Instructions	Shipped at 4 C. Upon delivery aliquot ａnd store at -20 C for one year. Avoid freeze/thaw cycles.
Storage Buffer	Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, ａnd 0.01% sodium azide.

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