标题PPM1A antibody Catalog Number：OM269348

提供者：上海笃玛生物科技有限公司发布时间：2024/9/11 阅读次数：21次 >>进入该公司展台

Product Name	PPM1A antibody
Antibody Type	Primary Antibodies
Product description	Mouse Monoclonal Antibody [7F12] to PPM1AThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, ａnd negatively regulates the activities of, MAP kinases ａnd MAP kinase kinases. It has been shown to inhibit the activation of p38 ａnd JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, ａnd thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest ａnd apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] More
Immunogen	The immunogen corresponding to a region within amino acids 202 ａnd 382 of human PPM1A expressed in E. Coli.

Clonality	Monoclonal
Isotype	IgG1
Clone Number	7F12
Host Species	Mouse
Tested Applications	ELISAFACSWB
	ELISA: 1/10000.:
Species Reactivity	HumanMonkey
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification

Application

ELISA analysis of control antigen ａnd antigen using PPM1A antibody [7F12].
Application

FACS analysis of HeLa cells using PPM1A antibody [7F12] (green) or a negative control (red).
Application

WB analysis of lysates from (1) untransfected ａnd (2) PPM1A (a.a. 202-382)-hIgGFc transfected HEK293 cells using PPM1A antibody [7F12].
Application

WB analysis of (1) Jurkat, (2) Jurkat, (3) A431, (4) HeLa, (5) HEK293, (6) Raji, (7) MCF-7 ａnd (8) COS7 lysates using PPM1A antibody [7F12].
Application

WB analysis of human PPM1A recombinant protein using PPM1A antibody [7F12].

Application Notes	ELISA: 1/10000.:

Form	Liquid
Storage Instructions	4°C; -20°C for long term storage
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide ａnd 0.5% protein stabilizer.

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