标题PPM1A Antibody (Center) Catalog Number：OM218462

提供者：上海笃玛生物科技有限公司发布时间：2024/9/12 阅读次数：18次 >>进入该公司展台

Product Name	PPM1A Antibody (Center)
Antibody Type	Primary Antibodies

Gene Synonyms	PPPM1A
Alternative Names	PPM1A PPPM1A Protein phosphatase 1A Protein phosphatase 2C isoform alpha Protein phosphatase IA Hide
Molecular Weight(MW)	42448 Da
Function	Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 ａnd SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs ａnd termination of the TGF-beta-mediated signaling
Tissue Specificity	This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64~94 amino acids from the center region of human PPM1A.
Cellular Localization	Nucleus.

Entrez Gene	5494

Application

Western blot analysis of hPPM1A-C72 (RB06012) in HL-60 cell line lysates (35ug/lane).PPM1A (arrow) was detected using the purified Pab.
Application

Western blot analysis of PPM1A (arrow) using rabbit polyclonal hPPM1A-C72 . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PPM1A gene (Lane 2) (Origene Technologies).
Application

Formalin-fixed ａnd paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Application Notes	WB~~1:100~500 IHC~~1:50~100:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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