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您的位置:首页 > 技术文献 > 产品说明 > Anti-RPA1 antibody Catalog Number:OM642633

标题Anti-RPA1 antibody Catalog Number:OM642633

   

提供者:上海笃玛生物科技有限公司    发布时间:2024/9/18   阅读次数:15次 >>进入该公司展台
 

Product Profile

Product Name Anti-RPA1 antibody
Antibody Type Primary Antibodies
Immunogen
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAIHC

 
IHC:1:200-1:2000
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Protein A

Target Information

Gene Symbol RPA1
Gene Synonyms
HSSB
RF-A
RP-A
REPA1
RPA70
MST075
PFBMFT6
More 
Gene Full Name replication protein A1
Gene Summary
This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017]
More 
Molecular Weight(MW) 68KD
Cellular Localization Nucleus

Application

  • IHC

    Immunohistochemical analysis of paraffin-embedded renal carcinoma tissues using RPA1 antibody with DAB staining.

  • IHC

    Immunohistochemical analysis of paraffin-embedded breast cancer tissues using RPA1 antibody with DAB staining.

Application Notes
IHC:1:200-1:2000

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.
 

关键词:稳定性强  特异性强    灵敏度高  

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