您的位置：首页 > 技术文献 > 产品说明 > Pkn2 Antibody (Center) Catalog Number：OM214357
| Product Name | Pkn2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB~~1:100~500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | More |
| Molecular Weight(MW) | 111607 Da |
| Function | PKC-related serine/threonine-protein kinase ａnd Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion ａnd transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes ａnd hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression ａnd abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed ａnd direction of movement during cell migration ａnd tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity Mediates Rho protein-induced transcriptional activation via the c- fos serum response factor (SRF) More |
| Tissue Specificity | Ubiquitous. Highly expressed in liver ａnd lung Expressed in astrocytes (at protein level). Ubiquitous |
| Cellular Localization | Cylasm. Nucleus (By similarity). Membrane. Cell projection, lamellipodium (By similarity) Cylasm, cytoskeleton (By similarity). Cleavage furrow (By similarity). Midbody (By similarity). Cell junction (By similarity). Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow ａnd concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells (By similarity) |
| Entrez Gene | 109333 |
|---|---|
| Nucleotide Accession | NP_848769.2 |
Mouse Pkn2 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Pkn2 antibody detected the Pkn2 protein (arrow).
| Application Notes | WB~~1:100~500: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
① 凡本网注明"来源：易推广"的所有作品，版权均属于易推广，未经本网授权不得转载、摘编或利用其它方式使用。已获本网授权的作品，应在授权范围内
使用，并注明"来源：易推广"。违者本网将追究相关法律责任。② 本信息由注册会员：上海笃玛生物科技有限公司 发布并且负责版权等法律责任。
易推广客服微信
