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| Product Name | Anti-BMI1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHCWB |
| WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | BMI1 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | BMI1 proto-oncogene, polycomb ring finger |
| Gene Summary | This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development ａnd self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene ａnd aberrant expression is associated with numerous cancers ａnd is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene ａnd the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015] More |
| Molecular Weight(MW) | 37KD |
| Cellular Localization | Cylasm, Nucleus |
Western blot analysis using BMI1 antibody against HepG2(1), A431(2) cell lysate.
Immunohistochemical analysis of paraffin-em
Immunofluorescence analysis of NIH3T3 cells using BMI1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
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