标题Rabbit anti-MBP polyclonal antibody - middle region Catalog Number：OM116494

WB:1:500~1:2000
IHC:1:50~1:200
IP:1:100~1:500
Notes:Optimal dilutions/concentrations should be determined by the researcher.

MGC99675

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T-cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. MBP induces T-cell proliferation.The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes ａnd Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow ａnd the immune system. These mRNAs arise from the long MBP gene (otherwise called ＇Golli-MBP＇) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli ａnd the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts ａnd gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons ａnd produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit ａnd that this arrangement is important for the function and/or regulation of these genes.

MGC99675

WB:1:500~1:2000
IHC:1:50~1:200
IP:1:100~1:500
Notes:Optimal dilutions/concentrations should be determined by the researcher.