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| Product Name | MBP Antibody (Ascites) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgM |
| Clone Number | 408CT17.4.3 |
| Host Species | Mouse |
| Tested Applications | WBIF |
| WB~~1:5000~16000 IF~~1:10~50: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Alternative Names | More |
|---|---|
| Molecular Weight(MW) | 33117 Da |
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T- cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation More |
| Tissue Specificity | MBP isoforms are found in both the central ａnd the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen ａnd spinal cord, as well as in cell lines derived from the immune system |
| Cellular Localization | Myelin membrane; Peripheral membrane protein; Cylasmic side. Note=Cylasmic side of myelin |
| Entrez Gene | 4155 |
|---|---|
| Nucleotide Accession | NP_001020261.1;NP_001020252.1 |
MBP Antibody (Ascites)(Cat. #AM2005a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the MBP antibody detected the MBP protein (arrow).
Confocal immunofluorescent analysis of MBP Antibody (Ascites)(Cat#AM2005a) with NCI-H460 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).
| Application Notes | WB~~1:5000~16000 IF~~1:10~50: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
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