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| Product Name | MBP Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1448Y |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB~~1:500: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Alternative Names | More |
|---|---|
| Molecular Weight(MW) | 33117 Da |
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T- cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation More |
| Tissue Specificity | MBP isoforms are found in both the central ａnd the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen ａnd spinal cord, as well as in cell lines derived from the immune system |
| Cellular Localization | Myelin membrane; Peripheral membrane protein; Cylasmic side. Note=Cylasmic side of myelin |
| Entrez Gene | 4155 |
|---|
A.Western blot analysis on fetal brain using anti-MBP RabMAb (Cat. #AJ1462a), dilution 1:5000.
B. Immunocytochemistry analysis of PC12 cells using anti-MBP RabMAb (Cat. #AJ1462a).
| Application Notes | WB~~1:500: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide ａnd 0.05% BSA. |
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