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您的位置:首页 > 技术文献 > 产品说明 > Rabbit anti-MCM7 polyclonal antibody - middle region Catalog Number:OM107936

标题Rabbit anti-MCM7 polyclonal antibody - middle region Catalog Number:OM107936

   

提供者:上海笃玛生物科技有限公司    发布时间:2024/9/27   阅读次数:31次 >>进入该公司展台
 

Product Profile

Product Name Rabbit anti-MCM7 polyclonal antibody - middle region
Antibody Type Primary Antibodies
Immunogen
The immunogen for anti-MCM7 antibody: synthetic peptide directed towards the middle region of human MCM7

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIHC

 
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

BovineHumanRabbitRat

Concentration 1 mg/ml
Purification Protein A

Target Information

Gene Symbol MCM7
Gene Synonyms
MCM2
CDC47
P85MCM
P1CDC47
PNAS146
P1.1-MCM3
More 
Gene Full Name Minichromosome maintenance complex component 7
Gene Summary
MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
More 
Alternative Names
MCM2
CDC47
P85MCM
P1CDC47
PNAS146
P1.1-MCM3
More 
Molecular Weight(MW) 81kDa
Sequence 719 amino acids

Database Links

Entrez Gene 4176
SwissProt ID P33993
Protein Accession NP_005907

Application

  • Western blot

    1.25ug/ml
    Positive Control: Daudi cell lysate

  • Immunohistochemical

     

Application Notes
WB:1:500~1:2000
IHC:1:50~1:200
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Aliquot and store at -20°C. Avoid repeated freeze / thaw cycles
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

关键词:稳定性强  特异性强    灵敏度高  

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