标题PSMB8 antibody Catalog Number：OM272736

提供者：上海笃玛生物科技有限公司发布时间：2024/9/27 阅读次数：32次 >>进入该公司展台

Product Name	PSMB8 antibody
Antibody Type	Primary Antibodies
Product description	Rabbit polyclonal antibody to PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits ａnd 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration ａnd cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon ａnd this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq] More
Immunogen	Recombinant protein encompassing a sequence within the center region of human PSMB8. The exact sequence is proprietary.

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	ICC/IFIHC-PWB
	*Optimal dilutions/concentrations should be determined by the researcher. :
Species Reactivity	HumanMouseRat
Predicted Reactivity	Japanese medaka, Xenopus laevis, Dog, Pig, Sheep, BovineJapanese medaka (80%), Xenopus laevis (83%), Dog (91%), Pig (94%), Sheep (93%), Bovine (93%)
Concentration	1 mg/ml
Purification	Affinity purified

Gene Synonyms	D6S216 antibody D6S216E antibody LMP7 antibody MGC1491 antibody PSMB5i antibody RING10 antibody PSMB8 antibody proteasome subunit Y2 antibody macropain subunit C13 antibody proteasome subunit beta type-8 antibody really interesting new gene 10 pr More
Target	PSMB8
Molecular Weight(MW)	30 kDa (note) (3)
Cellular Localization	Cylasm (By similarity) , Nucleus

Application

PSMB8 antibody [N2C3] detects PSMB8 protein at cytosol ａnd nucleus on mouse liver by immunohistochemical analysis. Sample: Paraffin-embedded mouse liver. PSMB8 antibody [N2C3] dilution: 1:250.
Application

Immunofluorescence analysis of paraformaldehyde-fixed A431, using PSMB8 antibody at 1:200 dilution.
Application

Immunohistochemical analysis of paraffin-embedded Cal27 Xenograft, using PSMB8 antibody at 1:100 dilution.
Application

Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE diluted at 1:1000

Positive Control	A431 , Molt-4 , Raji
Application Notes	*Optimal dilutions/concentrations should be determined by the researcher. :

Form	Liquid
Storage Instructions	Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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