标题GKAP [A3-G4] Catalog Number：OM627698

提供者：上海笃玛生物科技有限公司发布时间：2024/9/29 阅读次数：26次 >>进入该公司展台

Product Name	GKAP [A3-G4]
Antibody Type	Primary Antibodies
Product description	The neurotransmitter glutamate facilitates neuronal signalling at excitatory synapses. Glutamate is released from the presynaptic membrane into the synaptic cleft. Across the synaptic cleft glutamate binds to both ion channels ａnd metabotropic glutamate receptors at the postsynapse, which expedite downstream signalling in the neuron. The postsynaptic density, a highly specialized matrix, which is attached to the postsynaptic membrane, controls this downstream signalling. The postsynaptic density also resets the synapse after each synaptic firing. It is composed of numerous proteins including a family of Discs large associated protein 1, 2, 3 ａnd 4 (DLGAP1-4) that act as scaffold proteins in the postsynaptic density. They link the glutamate receptors in the postsynaptic membrane to other glutamate receptors, to signalling proteins ａnd to components of the cytoskeleton. With the central localisation in the postsynapse, the DLGAP family seems to play a vital role in synaptic scaling by regulating the turnover of both ionotropic ａnd metabotropic glutamate receptors in response to synaptic activity. DLGAP family has been directly linked to a variety of psychological ａnd neurological disorders. In this review we focus on the direct ａnd indirect role of DLGAP family on schizophrenia as well as other brain diseases. More
Immunogen	Recombinant protein

Alternative Names	cGMP dependent protein kinase anchoring protein 42kDa antibody cGMP dependent protein kinase anchoring protein of 42 kDa antibody cGMP-dependent protein kinase-anchoring protein of 42 kDa antibody FKSG21 antibody G kinase anchoring protein 1 antibody G kinase-anchoring protein 1 antibody gkap1 antibody GKAP1_HUMAN antibody GKAP42 antibody Protein kinase anchoring protein GKAP42 antibody More
Molecular Weight(MW)	109 kDa
Cellular Localization	Membrane.

SwissProt ID	O14490

Application

Fig1: Western blot analysis of DLGAP1 on HEK293 (1) ａnd DLGAP1-hIgGFc transfected HEK293 (2) cell lysate using anti- DLGAP1 antibody at 1/1,000 dilution.
Application

Fig2: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti- DLGAP1 antibody. Counter stained with hematoxylin.
Application

Fig3: Immunohistochemical analysis of paraffin-embedded human esophagus tissue using anti- DLGAP1 antibody. Counter stained with hematoxylin.
Application

Fig4: ICC staining DLGAP1 (green) ａnd actin filaments (red) in NIH/3T3 cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Positive Control	GKAP-hIgGFc transfected HEK293 cell lysate, human liver cancer tissue, human esophagus tissue, NIH/3T3.
Application Notes	WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Form	Liquid
Storage Instructions	Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer	1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

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