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| Product Name | SUMO2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB~~1:100~500 IHC~~1:50~100: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
| Gene Synonyms | |
|---|---|
| Alternative Names | |
| Molecular Weight(MW) | 10820 Da |
| Function | Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex sae1-sae2 ａnd linkage to the E2 enzyme ube2i, ａnd can be promoted by an E3 ligase such as pias1-4 This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication ａnd repair, mitosis ａnd signal transduction. Polymeric sumo2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins More |
| Tissue Specificity | This SUMO2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52~82 amino acids from the C-terminal region of Xenopus SUMO2. |
| Cellular Localization | Nucleus (By similarity). |
| Entrez Gene | 379777 |
|---|
The SUMO2 Pab is used in Western blot to detect SUMO2 in Jurkat cell lysate.
Formalin-fixed ａnd paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
| Application Notes | WB~~1:100~500 IHC~~1:50~100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high ａnd low pH buffers ａnd neutralized immediately, followed by dialysis against PBS. |
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