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TP1881L1Pep 2-8 ammonium salt(1541011-97-5 free base)Pep 2 8 ammonium salt(1541011 97 5 free base),Pep 28 am
Pep 2-8 ammonium salt is Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.
价 格:¥电议型 号:TP1881L1产 地:中国大陆
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TP1882L1Orphanin FQ(1-11) acetate(178249-41-7 free base)Orphanin FQ(1 11) acetate(178249 41 7 free base),Orp
Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
价 格:¥电议型 号:TP1882L1产 地:中国大陆
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TP1889MCL0020inhibit,Melanocortin Receptor,COS-1,Inhibitor,MCL0020,MC Receptor,anorexia,dose-dependently,s
Potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no effect on food intake in free-feeding rats. Exhibits anxiolytic-like activity in vivo.
价 格:¥电议型 号:TP1889产 地:中国大陆
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T7334NP118809NP118809,NP 118809,NP-118809,Inhibitor,inhibit,Ca2+ channels,Calcium Channel,Ca channels
NP118809 is a potent N-type calcium channel blocker(IC50 : 0.11 μM).
价 格:¥电议型 号:T7334产 地:中国大陆
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TCS1188Mogroside IIIinhibit,Mogroside III,Inhibitor
Mogroside III is a triterpenoid glycoside and a nonsugar sweetener. Mogroside III is transformed by human intestinal bacteria to release secondary glycoside mogroside IIA1 and aglycone mogrol.
价 格:¥电议型 号:TCS1188产 地:中国大陆
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TP1885L1[(pF)Phe4]Nociceptin(1-13)NH2 acetate[(pF)Phe4]Nociceptin(113)NH2 acetate,[(pF)Phe4]Nociceptin(1 13)
[(pF)Phe4]Nociceptin(1-13)NH2 acetate is a selective agonist of NOP receptor with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 acetate displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold).
价 格:¥电议型 号:TP1885L1产 地:中国大陆
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T6S1884Benzoylhypaconineinhibit,Inhibitor,Benzoylhypaconine
Benzoylhypacoitine might be the principal active components which affect mitochondrial growth by Fuzi and its processed products.
价 格:¥电议型 号:T6S1884产 地:中国大陆
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T8371ML188Inhibitor,SARS coronavirus,infection,non-covalent,ML-188,ML 188,ML188,antiviral,SARS-CoV,Virus
ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.
价 格:¥电议型 号:T8371产 地:中国大陆
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T101886RK736RK-73,6RK73
6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 ?M). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 ?M).
价 格:¥电议型 号:T10188产 地:中国大陆
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T12188NB-360Inhibitor,BACE,NB 360,β-Secretase,inhibit,NB-360,NB360,Beta-secretase
NB-360 is a potent and brain-penetrable inhibitor of BACE1 and BACE2 with IC50s of 5, 5, and 6 nM for mouse and human BACE1 and BACE2. NB-360 exhibits excellent selectivity over the related aspartyl proteases pepsin, cathepsin E, and cathepsin D.
价 格:¥电议型 号:T12188产 地:中国大陆
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T70421,5-IsoquinolinediolPARP,diabetic,1188540,oxidative,retinopathy,1,5 Isoquinolinediol,stress,inhibit,
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol has been used to study the role of PARP1 in both DNA repair and oxidant stress-induced cell death. This compound can be used with cells in culture and in animals.
价 格:¥电议型 号:T7042产 地:中国大陆
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TP2111LTAT-GluA2 3Y acetate(1404188-93-7 free base)TAT-GluA-2 3Y acetate(1404188-93-7 free base),TATGluA2 3
TAT-GluA2 3Y acetate is an inhibitor of AMPA receptor endocytosis. Induces increased hind paw withdrawal latencies following thermal and mechanical stimuli in rats. Also exhibits antinociceptive effects in a rat model of neuropathic pain. Rescues pentobarbital-induced memory retrieval deficits in a rat model of learning and memory.
价 格:¥电议型 号:TP2111L产 地:中国大陆
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TP1884L1Neuropeptide SF(mouse,rat) acetateNeuropeptide SF(mouse,rat) acetate
Neuropeptide SF (mouse,rat) acetate is a potent neuropeptide FF receptor agonist, Ki for NPFF1 and NPFF2 are 48.4 nM and 12.1 nM, respectively. Neuropeptide SF (mouse,rat) acetate increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3).
价 格:¥电议型 号:TP1884L1产 地:中国大陆
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T6S1880BenzoylaconineInhibitor,Benzoylaconine,inhibit
Benzoylaconine is an alkaloid in the Chinese traditional medicine Radix Aconiti Lateralis Preparata (Fuzi). Benzoylaconine and aconitine can induce reproductive toxicity in BeWo Cell, the amino acid metabolism was the main metabolic pathway and responsible for the placental and fetal toxicity of them.
价 格:¥电议型 号:T6S1880产 地:中国大陆
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TN5283L-Cysteine hydrochloride hydrateInhibitor,semi-essential,anorectic,endogenous,1880366,L-Cysteine hyd
L-Cysteine hydrochloride hydrate is a conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), taurine and glutathione. L-Cysteine hydrochloride hydrate suppresses ghrelin and reduces appetite in rodents and humans.
价 格:¥电议型 号:TN5283产 地:中国大陆
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T8382Cariprazine hydrochlorideDopamine Receptor,Cariprazine,5-hydroxytryptamine Receptor,RGH188,Inhibitor
Cariprazine HCl is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)
价 格:¥电议型 号:T8382产 地:中国大陆
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T8188PodophyllotoxoneInhibitor,DU145,inhibit,Podophyllotoxone,cancer,Microtubule/Tubulin,PC3,cells,prosta
Podophyllotoxinone, a natural compound found in Dysosma versipellis, shows inhibitory activity against L1210 leukemia and KB cells in vitro.
价 格:¥电议型 号:T8188产 地:中国大陆
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T8572CL 218872GABA Receptor,Gamma-aminobutyric acid Receptor,CL218872,CL 218872,γ-Aminobutyric acid Recep
CL 218872 is a benzodiazepine agonist displaying selectivity for α1 subunit-containing GABAA receptors (Ki values are 130, 1820, 1530, > 10000, 490 and > 10000 nM for α1, α2, α3, α4, α5 and α6-subunit containing receptors respectively). Orally active anxiolytic and anticonvulsant in vivo.
价 格:¥电议型 号:T8572产 地:中国大陆
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T6S1885BenzoylmesaconineInhibitor,inhibit,Benzoylmesaconine
Benzoylmesaconine is the most abundant component of Wutou decoction, which is widely used in China because of its therapeutic effect on rheumatoid arthritis. Benzoylmesconine has analgesic activity. Benzoylmesconine may improve the resistance of T6S-mice (or thermally injured mice) to the infection of HSV-1, through the induction of antagonistic CD4+ T cells against burn-associated type-2 T cells.
价 格:¥电议型 号:T6S1885产 地:中国大陆
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TP1886L1NoxA1ds acetate(1435893-78-9 free base)NoxA1ds acetate(1435893 78 9 free base),NoxA-1ds acetate(1435
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
价 格:¥电议型 号:TP1886L1产 地:中国大陆