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  • T3964Glutaminase C-IN-1Compound 968；Glutaminase Inhibitor Compound 968

    Glutaminase C-IN-1 is a Glutaminase C allosteric inhibitor.

    价 格：￥电议型 号：T3964产 地：中国大陆

  • T11735K-Ras G12C-IN-1K-Ras G12C-IN-1

    K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.

    价 格：￥电议型 号：T11735产 地：美洲

  • T12494PKC-IN-1PKC-IN-1

    PKC-IN-1 is a ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6, 25.6, 57.5, 314, 808 nM , respectively).

    价 格：￥电议型 号：T12494产 地：美洲

  • T15605JAK/HDAC-IN-1JAK/HDAC-IN-1

    JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor. JAK/HDAC-IN-1 has an IC50s of 4 and 2 nM for JAK2 and HDAC, respectively. It also shows antiproliferative and proapoptotic activities in several hematological cell lines.

    价 格：￥电议型 号：T15605产 地：美洲

  • T82950ATIC-IN-1；化合物 ATIC-IN-1ATIC-IN-1

    ATIC-IN-1 (compound 14) serves as an inhibitor specifically aimed at the dimerization of Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC), with a K i of 685 nM. This dimerization is essential for the enzyme´s aminoimidazole carboxamide ribonucleotide (AICAR) transformylase function. Furthermore, ATIC-IN-1 demonstrates anti-tumor properties by diminishing both cell proliferation and cell division rates [1].

    价 格：￥电议型 号：T82950产 地：中国大陆

  • T79713JMJD3/HDAC-IN-1；化合物 JMJD3/HDAC-IN-1JMJD3/HDAC-IN-1

    Compound A5b, also known as JMJD3/HDAC-IN-1, is a dual inhibitor that targets both JMJD3 (Jumonji domain-containing protein demethylase 3) and HADC1 (histone deacetylase, IC50 = 16 nM). It induces hypermethylation of histone H3K27 and hyperacetylation of H3K9, while also promoting apoptosis through the cleavage of caspase-7 and PARP. This compound has demonstrated the ability to effectively inhibit cancer cell cloning, migration, and invasion [1].

    价 格：￥电议型 号：T79713产 地：中国大陆

  • T78159ATIC-IN-1 acetate；化合物 ATIC-IN-1 acetateATIC-IN-1 acetate

    ATIC-IN-1 (compound 14) acetate is an ATIC dimerization inhibitor with a K i value of 685 nM, essential for AICAR transformylase activity. It demonstrates anti-tumor effects by decreasing cell proliferation and division rates [1].

    价 格：￥电议型 号：T78159产 地：中国大陆

  • T74979HCVcc-IN-1；化合物 HCVcc-IN-1HCVcc-IN-1

    HCVcc-IN-1, a derivative of benzothiazole-2-thiophene S-glycoside, exhibits low toxicity and antiviral properties [1].

    价 格：￥电议型 号：T74979产 地：中国大陆

  • T73995EGFR/CSC-IN-1；化合物 EGFR/CSC-IN-1EGFR/CSC-IN-1

    EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential applications in triple-negative breast cancer research.

    价 格：￥电议型 号：T73995产 地：中国大陆

  • T72946G4/HDAC-IN-1；化合物 G4/HDAC-IN-1G4/HDAC-IN-1

    G4/HDAC-IN-1, a dual-targeting compound for G4 and HDAC, shows inhibition of intracellular HDAC activity, with an IC50 value of 1.1 μM, and promotes G4 formation. It effectively inhibits proliferation and tumor growth in a TNBC xenograft model, presenting potential for cancer research applications.

    价 格：￥电议型 号：T72946产 地：中国大陆

  • T72839SHP2/HDAC-IN-1；化合物 SHP2/HDAC-IN-1SHP2/HDAC-IN-1

    SHP2/HDAC-IN-1, a dual allosteric inhibitor targeting SHP2 and HDAC, exhibits potent inhibitory effects with IC 50 values of 20.4 nM (SHP2) and 25.3 nM (HDAC1), respectively. This compound activates T cells, enhances antigen presentation, and promotes cytokine secretion, facilitating efficient antitumor immunity. It holds potential for cancer immunotherapy research.

    价 格：￥电议型 号：T72839产 地：中国大陆

  • T64154CYP51/HDAC-IN-1；化合物 CYP51/HDAC-IN-1CYP51/HDAC-IN-1

    CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective therapeutic effects in both Candidiasis tropicalis and Cryptococcal meningitis.

    价 格：￥电议型 号：T64154产 地：中国大陆

  • T63907PDE5/HDAC-IN-1；化合物 PDE5/HDAC-IN-1PDE5/HDAC-IN-1

    PDE5/HDAC-IN-1 is a potent inhibitor of phosphodiesterase 5 (PDE5) and HDAC, with IC50 values of 46.3 nM and 14.5 nM, respectively.

    价 格：￥电议型 号：T63907产 地：中国大陆

  • T63512LpxC-IN-10；化合物 LpxC-IN-10LpxC-IN-10

    LpxC-IN-10 is a selective LpxC inhibitor with an MIC of 0.5 μg/mL against E. coli and K. pneumoniae and is capable of being used to study bacterial infections.

    价 格：￥电议型 号：T63512产 地：中国大陆

  • T63509Top/HDAC-IN-1；化合物 Top/HDAC-IN-1Top/HDAC-IN-1

    Top/HDAC-IN-1 is a dual topoisomerase (Top)/HDAC inhibitor that acts on HDAC1 (IC50: 18 nM), HDAC2 (IC50: 230 nM), HDAC3 (IC50: 790 nM), HDAC6 (IC50: 87 nM) and HDAC8 (IC50: 5250 nM). Top/HDAC-IN-1 exhibited potent antitumor effects on HCT116 cells (IC50: 180 nM), blocked the cell cycle of HCT116 cells in G2 phase, and effectively induced apoptosis.

    价 格：￥电议型 号：T63509产 地：中国大陆

  • T63399LmTOR/HDAC-IN-1 HCl；mTOR/HDAC抑制剂1盐酸盐mTOR/HDAC-IN-1 HCl（2815286-02-1 Free base)；mTOR/HDAC-IN-1 HCl（281

    mTOR/HDAC-IN-1 HCl is a potent dual inhibitor of mTOR and HDAC with potential anti-inflammatory, anti-proliferative, autophagy and apoptosis-inducing effects for cancer research.

    价 格：￥电议型 号：T63399L产 地：中国大陆

  • T63399mTOR/HDAC-IN-1；化合物 mTOR/HDAC-IN-1mTOR/HDAC-IN-1

    mTOR/HDAC-IN-1 (Compound 50) is a dual inhibitor targeting both mTOR and HDAC with respective IC50 values of 0.49 nM and 0.91 nM. It holds potential as an anti-cancer agent [1].

    价 格：￥电议型 号：T63399产 地：中国大陆

  • T63260Snail/HDAC-IN-1；Snail/HDAC 抑制剂1Snail/HDAC-IN-1

    Snail/HDAC-IN-1 is a Snail/HDAC inhibitor agent with antimicrobial and anticancer activity, reduces Snail protein expression, induces apoptosis, and can be used in the study of solid tumors.

    价 格：￥电议型 号：T63260产 地：中国大陆

  • T63142AChE/HDAC-IN-1；化合物 AChE/HDAC-IN-1AChE/HDAC-IN-1

    COX-2-IN-23 (compound A10) is a potent inhibitor of AChE (IC50: 0.12 nM) and HDAC (IC50: 0.23 nM).COX-2-IN-23 exhibits antioxidant and metal chelating properties.COX-2-IN-23 can be used to study Alzheimer´s disease.

    价 格：￥电议型 号：T63142产 地：中国大陆

  • T62945Aurora A/PKC-IN-1；化合物 Aurora A/PKC-IN-1Aurora A/PKC-IN-1

    Aurora A/PKC-IN-1 (Compound 2e) is a potent dual inhibitor of Aurora A (AurA) and PKC (α, β1, β2, θ), acting on AurA (IC50: 6.9 nM) and PKCα (IC50: 16.9 nM). Aurora A/PKC-IN-1 showed anti-proliferative and anti-metastatic effects on breast cancer cells.

    价 格：￥电议型 号：T62945产 地：中国大陆

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