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T6327Tubacin
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
价 格:¥电议型 号:T6327产 地:中国大陆
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T1983CAY10603HDAC6 Inhibitor;BML-281
CAY10603 is a potent and selective inhibitor of HDAC6.
价 格:¥电议型 号:T1983产 地:中国大陆
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T1983CAY10603CAY10603,BML-281,HDAC6 Inhibitor
CAY10603 is a potent and selective inhibitor of HDAC6.
价 格:¥电议型 号:T1983产 地:美洲
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T82226HDAC6-IN-21;化合物 HDAC6-IN-21HDAC6-IN-21
HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histone deacetylase 6 (HDAC6) [1].
价 格:¥电议型 号:T82226产 地:中国大陆
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T82225HDAC6-IN-24;化合物 HDAC6-IN-24HDAC6-IN-24
HDAC6-IN-24 (compound N1) is an inhibitor of histone deacetylase 6 (HDAC6) [1].
价 格:¥电议型 号:T82225产 地:中国大陆
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T82224HDAC6-IN-25;化合物 HDAC6-IN-25HDAC6-IN-25
HDAC6-IN-25 (compound 8) is a potent and selective HDAC6 inhibitor, exhibiting an IC50 value of 0.6 nM [1].
价 格:¥电议型 号:T82224产 地:中国大陆
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T79771HDAC6-IN-22;化合物 HDAC6-IN-22HDAC6-IN-22
HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and in vivo. It induces cell cycle arrest in the G2 phase and promotes apoptosis via the mitochondrial pathway [1].
价 格:¥电议型 号:T79771产 地:中国大陆
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T79769HDAC6-IN-23;化合物 HDAC6-IN-23HDAC6-IN-23
HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.
价 格:¥电议型 号:T79769产 地:中国大陆
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T79710PI3Kα/HDAC6-IN-1;化合物 PI3Kα/HDAC6-IN-1PI3Kα/HDAC6-IN-1
PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated α-tubulin, while not influencing acetylated histones H3 and H4. The compound demonstrates potent anti-cancer efficacy by inhibiting the L-363 cell line with an IC50 of 0.17 μM [1].
价 格:¥电议型 号:T79710产 地:中国大陆
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T79523HDAC6-IN-18;化合物 HDAC6-IN-18HDAC6-IN-18
HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory activity with IC50 values of 0.17, 0.7, and 0.42 μM in RPMI8266, U266, and MM.1S cells, respectively [1].
价 格:¥电议型 号:T79523产 地:中国大陆
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T78839HDAC6-IN-19;化合物 HDAC6-IN-19HDAC6-IN-19
HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, and 103 nM, respectively. This compound effectively suppresses the proliferation of various cancer cell lines, such as leukemia, colon cancer, melanoma, and breast cancer [1].
价 格:¥电议型 号:T78839产 地:中国大陆
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T78799BChE/HDAC6-IN-1;化合物 BChE/HDAC6-IN-1BChE/HDAC6-IN-1
BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42-induced mouse model, indicating its potential utility in Alzheimer´s disease research [1].
价 格:¥电议型 号:T78799产 地:中国大陆
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T78769HDAC6-IN-17;化合物 HDAC6-IN-17HDAC6-IN-17
HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is utilized in cancer research [1].
价 格:¥电议型 号:T78769产 地:中国大陆
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T78768HDAC6-IN-16;化合物 HDAC6-IN-16HDAC6-IN-16
HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing apoptosis [1].
价 格:¥电议型 号:T78768产 地:中国大陆
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T77922HDAC6 degrader-1;化合物 HDAC6 degrader-1HDAC6 degrader-1
HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effectively induces HDAC6 degradation, displays superior selectivity over other HDAC isoforms, and efficiently inhibits cell proliferation [1].
价 格:¥电议型 号:T77922产 地:中国大陆
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T75017PROTAC HDAC6 degrader 1;化合物 PROTAC HDAC6 degrader 1PROTAC HDAC6 degrader 1
Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].
价 格:¥电议型 号:T75017产 地:中国大陆
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T74617HDAC6-IN-8;化合物 HDAC6-IN-8HDAC6-IN-8
Compound 12C, modified by altering cap groups, exhibits broad-spectrum enzyme inhibitory activity, as demonstrated in enzyme inhibition assays. Conversely, compounds 9m and 9q display a predilection towards HDAC6 inhibition, indicating subtype-selective inhibitory properties among the tested variants.
价 格:¥电议型 号:T74617产 地:中国大陆
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T73043HDAC6-IN-15;化合物 HDAC6-IN-15HDAC6-IN-15
HDAC6-IN-15, a selective histone deacetylase 6 (HDAC6) inhibitor, exhibits potent inhibitory activity with an IC50 value of 38.2 nM, making it valuable for research in cancer and neurodegenerative diseases.
价 格:¥电议型 号:T73043产 地:中国大陆
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T73031HDAC6-IN-14;化合物 HDAC6-IN-14HDAC6-IN-14
HDAC6-IN-14, an inhibitor of HDAC6 (HDAC), exhibits high selectivity with an IC50 value of 42 nM, demonstrating over 100-fold selectivity compared to HDAC1, HDAC2, HDAC3, and HDAC4.
价 格:¥电议型 号:T73031产 地:中国大陆
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T69753HDAC6 degrader 9c;HDAC6 降解剂9cHDAC6 degrader 9c
HDAC6 degrader 9c is a small molecule histone deacetylase 6 (HDAC6) degrader that can be used to study cancer or other diseases.
价 格:¥电议型 号:T69753产 地:中国大陆