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  • T8958PU-H54inhibit,PUH54,PU-H54,Grp94,Inhibitor,PU-H-54,Hsp90α,HSP,Heat shock proteins,Grp94 inhibitor,Tr

    PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.

    价 格：￥电议型 号：T8958产 地：中国大陆

  • T6609NMS-E973NMS-E973,Leukemia,NMS E973,inhibit,HSP,Heat shock proteins,Adenocarcinoma,Hsp90α,ovary,colon

    NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.

    价 格：￥电议型 号：T6609产 地：中国大陆

  • T8858DTHIBdegradation,HSP27,Inhibitor,inhibit,HSP70,HSF1,HSP,DTHIB,HSP90,cancer,nuclear,anticancer,Heat s

    DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.

    价 格：￥电议型 号：T8858产 地：中国大陆

  • T82166HSP90-IN-27；化合物 HSP90-IN-27HSP90-IN-27

    HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].

    价 格：￥电议型 号：T82166产 地：中国大陆

  • T79487MAO A/HSP90-IN-2；化合物 MAO A/HSP90-IN-2MAO A/HSP90-IN-2

    MAO A/HSP90-IN-2 (compound 4-C), a dual inhibitor of HSP90 and MAO A, exhibits IC50 values of 0.016 μM for MAO A and 4.58 μM for HSP90. This compound not only enhances HSP70 expression but also diminishes HER2 and phospho-Akt levels, and downregulates IFN-γ-induced PD-L1 expression in GL26 cells. Demonstrating efficacy against Temozolomide-sensitive and -resistant GBM cells, colon cancer, leukemia, non-small cell lung cancer, and other malignancies, MAO A/HSP90-IN-2 may also impede tumor immune

    价 格：￥电议型 号：T79487产 地：中国大陆

  • T79486MAO A/HSP90-IN-1；化合物 MAO A/HSP90-IN-1MAO A/HSP90-IN-1

    MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, exhibiting IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs the activities of MAO A, disrupts HSP90 binding, and downregulates both HER2 and phospho-Akt expressions, thereby inhibiting GBM growth. Additionally, it diminishes PD-L1 expression, thereby thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor

    价 格：￥电议型 号：T79486产 地：中国大陆

  • T79323PROTAC Hsp90α degrader 1；化合物 PROTAC Hsp90α degrader 1PROTAC Hsp90α degrader 1

    Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibitory effects on the proliferation of breast cancer cell lines, MDA-MB-231, MDA-MB-468, MCF-7, and MX-1, with respective IC50 values of 51.48 μM, 16.46 μM, 8.93 μM, and 11.95 μM [1].

    价 格：￥电议型 号：T79323产 地：中国大陆

  • T79083HSP90-IN-22；化合物 HSP90-IN-22HSP90-IN-22

    HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKBr3 breast cancer cells.

    价 格：￥电议型 号：T79083产 地：中国大陆

  • T78942HSP90-IN-23；化合物 HSP90-IN-23HSP90-IN-23

    HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrests their cell cycle at the G0/G1 phase, making it applicable for cancer research [1].

    价 格：￥电议型 号：T78942产 地：中国大陆

  • T78863HSP90-IN-25；化合物 HSP90-IN-25HSP90-IN-25

    HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].

    价 格：￥电议型 号：T78863产 地：中国大陆

  • T73835PROTAC HSP90 degrader BP3；化合物 PROTAC HSP90 degrader BP3PROTAC HSP90 degrader BP3

    PROTAC HSP90 degrader BP3 potently and selectively degrades HSP90 through a CRBN-dependent mechanism. It effectively diminishes HSP90 protein levels in MCF-7 cells with a half-maximal degradation concentration (DC50) of 0.99 ?M. Additionally, this compound impedes the proliferation of breast cancer cells [1].

    价 格：￥电议型 号：T73835产 地：中国大陆

  • T73038HSP90-IN-19；化合物 HSP90-IN-19HSP90-IN-19

    HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with an IC50 of 0.27 μM. It is utilized in the research of viral infections, neurodegenerative diseases, and inflammation [1].

    价 格：￥电议型 号：T73038产 地：中国大陆

  • T73037HSP90-IN-18；化合物 HSP90-IN-18HSP90-IN-18

    HSP90-IN-18 is a potent inhibitor of heat shock protein 90 (Hsp90), demonstrating significant inhibitory activity with an IC50 value of 0.39 μM. It is applicable in the research of viral infections, neurodegenerative diseases, and inflammation.

    价 格：￥电议型 号：T73037产 地：中国大陆

  • T73011HSP90-IN-20；化合物 HSP90-IN-20HSP90-IN-20

    HSP90-IN-20, a potent inhibitor of HSP90, exhibits an IC50 of ≤10 μM, indicating its potential application in cancer research.

    价 格：￥电议型 号：T73011产 地：中国大陆

  • T72996Hsp90-IN-17；化合物 Hsp90-IN-17Hsp90-IN-17

    Hsp90-IN-17 (Example 5) is an inhibitor of HSP90, applicable in researching proliferative diseases, including cancer and neurodegenerative conditions.

    价 格：￥电议型 号：T72996产 地：中国大陆

  • T72780HSP90/mTOR-IN-1；化合物 HSP90/mTOR-IN-1HSP90/mTOR-IN-1

    HSP90/mTOR-IN-1 is an effective and orally administrable inhibitor targeting both Hsp90 and mTOR, displaying IC50 values of 69 nM and 29 nM, respectively. This compound inhibits the proliferation of SW780 cells by overly activating the PI3K/AKT/mTOR pathway and induces apoptosis and autophagy through its selective inhibition of Hsp90 and mTOR. Additionally, HSP90/mTOR-IN-1 exhibits significant anti-tumor activity in vivo and is applicable in bladder cancer research.

    价 格：￥电议型 号：T72780产 地：中国大陆

  • T72225Hsp90-IN-17 hydrochloride；化合物 Hsp90-IN-17 hydrochlorideHsp90-IN-17 hydrochloride

    Hsp90-IN-17 (Example 5) hydrochloride, an HSP90 inhibitor, has potential applications in the research of proliferative conditions including cancer and neurodegenerative diseases.

    价 格：￥电议型 号：T72225产 地：中国大陆

  • T64263HSP90-IN-9；化合物 HSP90-IN-9HSP90-IN-9

    HSP90-IN-9 is a selective and potent HSP90 inhibitor.HSP90-IN-9 exhibits a dose-dependent fungicidal effect.HSP90-IN-9 in combination with FLC inhibits fungal biofilm formation and fungal morphological changes.HSP90-IN-9 downregulates ERG11, CDR1 and CDR2 gene expression and restores resistance to FLC. HSP90-IN-9 downregulates ERG11, CDR1 and CDR2 gene expression and restores FLC resistance.

    价 格：￥电议型 号：T64263产 地：中国大陆

  • T64261HDAC/HSP90-IN-4；化合物 HDAC/HSP90-IN-4HDAC/HSP90-IN-4

    HDAC/HSP90-IN-4 significantly inhibited HDAC and HSP90 activity, with compound 20 (HDACIC50= 194 nM; HSP90αIC50= 153 nM) and compound 26 ((HDACIC50= 360 nM; HSP90αIC50= 77 nM) having the strongest HDAC and HSP90α inhibition. effect. Both compounds induced HSP90 expression and down-regulated HSP90 client proteins, which play an important role in the regulation of cancer cell survival and invasion.

    价 格：￥电议型 号：T64261产 地：中国大陆

  • T63828Hsp90-IN-16；化合物 Hsp90-IN-16Hsp90-IN-16

    Hsp90-IN-16 is an HSP90 inhibitor that acts effectively and highly selectively on HER2-positive cancer cells.Hsp90-IN-16 inhibits the proliferation of HCC1954 breast cancer cells with an IC50 value of 6 μM.Hsp90-IN-16 inhibits HSP90 "client "proteins, including a key oncogenic receptor HER2/neu, induced apoptosis in cancer cells.

    价 格：￥电议型 号：T63828产 地：中国大陆

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