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  • T0794Mepenzolate BromideHCAR2,PUMA-G,inhibit,Muscarinic acetylcholine receptor,Inhibitor,hM3R,gastrointes

    Mepenzolate Bromide is a muscarinic antagonist used to treat gastrointestinal conditions.

    价 格：￥电议型 号：T0794产 地：中国大陆

  • T6503Fluorometholone AcetateInhibitor,Carbonate dehydratase,Fluorometholone,Fluorometholone Acetate,hCA-I

    Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.

    价 格：￥电议型 号：T6503产 地：中国大陆

  • T8827EMAC10101dEMAC-10101d,Carbonic Anhydrase,hCA II,EMAC10101d,Inhibitor,inhibit,Carbonate dehydratase

    compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.

    价 格：￥电议型 号：T8827产 地：中国大陆

  • T7506Yoda 1KcsA,Potassium Channel,Akt,Yoda-1,PKB,Inhibitor,A431 cells,Yoda 1,HCAECs,inhibit,Protein kinas

    Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)

    价 格：￥电议型 号：T7506产 地：中国大陆

  • TQ0108MK-6892HCAR2,PUMA-G,MK-6892,HM74A,HCA2,Inhibitor,GPR109A,MK6892,inhibit,MK 6892

    MK-6892 is a selective and full agonist for the high-affinity nicotinic acid receptor GPR109A (Ki: 4 nM; GTPγS EC50: 16 nM).

    价 格：￥电议型 号：TQ0108产 地：中国大陆

  • T83699LL-37 (18-37) (human) TFA；化合物 LL-37 (18-37) (human) TFAKR-20|||hCAP-18|||CAP-18|||Cathelicidin|||FAL

    LL-37 (18-37), an antimicrobial peptide fragment of LL-37, exhibits activity against S. aureus and C. albicans, with minimum lethal concentrations of 4 ?M and 10 ?M, respectively. Additionally, it inhibits E. histolytica trophozoites growth at concentrations between 10 to 50 ?M.

    价 格：￥电议型 号：T83699产 地：中国大陆

  • T82235hCA/Wnt/β-catenin-IN-1；化合物 hCA/Wnt/β-catenin-IN-1hCA/Wnt/β-catenin-IN-1

    hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-gp activity and impedes the Wnt/β-catenin signaling pathway. Furthermore, it compromises the viability of cancer cells, specifically targeting the NCI/ADR-RES DOX-resistant cell line [1].

    价 格：￥电议型 号：T82235产 地：中国大陆

  • T82234hCAIX-IN-19；化合物 hCAIX-IN-19hCAIX-IN-19

    hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/hCAIX = 117).

    价 格：￥电议型 号：T82234产 地：中国大陆

  • T82233HCAR2 agonist 1；化合物 HCAR2 agonist 1HCAR2 agonist 1

    HCAR2 agonist 1 (Compound 9n), a G i protein-biased allosteric modulator of HCAR2, activates the G i protein signaling pathway and exhibits anti-inflammatory properties by reducing mRNA levels of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and MCP-1). Additionally, it potentiates the anti-inflammatory effects of orthosteric agonists in a mouse model of colitis [1].

    价 格：￥电议型 号：T82233产 地：中国大陆

  • T80663hCAI/II/IV-IN-28；化合物hCAI/II/IV-IN-28WAY-638358；WAY-638358

    hCAI/II/IV-IN-28(WAY-638358) is a potent carbonic anhydrase inhibitor with potential anticonvulsant activity.

    价 格：￥电议型 号：T80663产 地：中国大陆

  • T79753hCAIX/XII-IN-8；化合物 hCAIX/XII-IN-8hCAIX/XII-IN-8

    hCAIX/XII-IN-8 (compound 3g) is a potent inhibitor of the human carbonic anhydrases (CAs) IX and XII, with inhibition constants (K i) of 8.5 nM for CA IX and 6.7 nM for CA XII. It demonstrates significant inhibitory efficacy particularly against tumor-associated, membrane-bound isoforms hCA IX and XII, while exhibiting a high selectivity over the cytosolic isoforms hCA I and II [1].

    价 格：￥电议型 号：T79753产 地：中国大陆

  • T79748hCAIX/XII-IN-7；化合物 hCAIX/XII-IN-7hCAIX/XII-IN-7

    Compound 3e (hCAIX/XII-IN-7) is a potent inhibitor of human carbonic anhydrase (hCA) isozymes IX and XII, displaying inhibitory constants (Kis) of 503.7 nM for hCA IX and 59 nM for hCA XII, while also showing activity against hCA I and II with Kis of 3.2 nM and 9.2 nM, respectively. It holds potential for research into hypoxic tumors [1].

    价 格：￥电议型 号：T79748产 地：中国大陆

  • T79591hCA/VEGFR-2-IN-4；化合物 hCA/VEGFR-2-IN-4hCA/VEGFR-2-IN-4

    hCA/VEGFR-2-IN-4 (compound 15b), an indolinylbenzenesulfonamide, serves as a potential dual inhibitor targeting cancer-related human carbonic anhydrases hCA IX/XII and vascular endothelial growth factor receptor 2 (VEGFR-2). It exhibits an IC50 value of 0.811 ?M against VEGFR-2 and demonstrates high affinity for hCAs, with inhibition constants (Ki) of 3.8 nM for hCA XII, 6.2 nM for hCA IX, 19.8 nM for hCA II, and 35.5 nM for hCA I. Additionally, the compound shows antiproliferative effects on br

    价 格：￥电议型 号：T79591产 地：中国大陆

  • T79588hCA/VEGFR-2-IN-3；化合物 hCA/VEGFR-2-IN-3hCA/VEGFR-2-IN-3

    hCA/VEGFR-2-IN-3 (compound 8j) is an indolinonylbenzenesulfonamide with potential as a dual inhibitor of cancer-associated hCA IX/XII and VEGFR-2. This compound inhibits VEGFR-2 with an IC50 of 358 nM and exhibits high affinity for hCAs, evidenced by Ki values of 4.2 nM for hCA IX, 22.9 nM for hCA II, 25.1 nM for hCA I, and 28.0 nM for hCA XII. Additionally, hCA/VEGFR-2-IN-3 demonstrates antiproliferative activity specifically against breast cancer cells that overexpress VEGFR-2 [1].

    价 格：￥电议型 号：T79588产 地：中国大陆

  • T79587hCA/VEGFR-2-IN-2；化合物 hCA/VEGFR-2-IN-2hCA/VEGFR-2-IN-2

    Compound 8g (hCA/VEGFR-2-IN-2) is an indolinonylbenzenesulfonamide identified as a potential dual inhibitor targeting cancer-associated isozymes hCA IX/XII and the angiogenic receptor VEGFR-2. It demonstrates VEGFR-2 inhibition with an IC50 of 204 nM and high affinity for hCAs, exhibiting Kis of 3.6 nM for hCA IX, 16.1 nM for hCA II, 16.7 nM for hCA XII, and 75.3 nM for hCA I. Furthermore, compound 8g exhibits antiproliferative effects on breast cancer cells overexpressing VEGFR-2 [1].

    价 格：￥电议型 号：T79587产 地：中国大陆

  • T79540hCA/VEGFR-2-IN-1；化合物 hCA/VEGFR-2-IN-1hCA/VEGFR-2-IN-1

    hCA/VEGFR-2-IN-1 (compound 13a) is a potent dual inhibitor targeting both Carbonic Anhydrase (CA) IX/XII and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2). It exhibits Ki values of 4.7 nM for hCA XII and 8.3 nM for hCA IX, alongside an IC50 of 26.3 nM for VEGFR-2. This compound demonstrates anticancer activity [1].

    价 格：￥电议型 号：T79540产 地：中国大陆

  • T79411hCAXII-IN-7；化合物 hCAXII-IN-7hCAXII-IN-7

    hCAXII-IN-7 (compound 6e) functions as an inhibitor of human carbonic anhydrase XII (hCA XII) and possesses blood-brain barrier (BBB) permeability. Moreover, it promotes apoptosis in 786-0, SF-539, and HS 578 T cell lines [1].

    价 格：￥电议型 号：T79411产 地：中国大陆

  • T78789hCA XII-IN-6；化合物 hCA XII-IN-6hCA XII-IN-6

    Compound 4d, known as hCA XII-IN-6, is a potent inhibitor of human carbonic anhydrase XII (hCA XII) with a Ki value of 84.2 nM and exhibits anti-proliferative effects, making it useful in cancer research [1].

    价 格：￥电议型 号：T78789产 地：中国大陆

  • T78729hCAIX/VII-IN-1；化合物 hCAIX/VII-IN-1hCAIX/VII-IN-1

    hCAIX/VII-IN-1 is a selective inhibitor of human carbonic anhydrase isoforms VII and IX. It displays inhibitory activity against hCA I, II, IV, VII, and IX, with respective K_i values of 336.2 nM, 185.8 nM, 1055 nM, 35.6 nM, and 28.0 nM. This compound is applicable in cancer and neurological disease research [1].

    价 格：￥电议型 号：T78729产 地：中国大陆

  • T74978DPP IV/hCA II-IN-1；化合物 DPP IV/hCA II-IN-1DPP IV/hCA II-IN-1

    DPP IV/hCA II-IN-1 is a potent, selective inhibitor of dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA), exhibiting an IC50 of 0.049 μM for DPP IV and K_i values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively [1].

    价 格：￥电议型 号：T74978产 地：中国大陆

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