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T81204SARS-CoV-2-IN-67；化合物 SARS-CoV-2-IN-67SARS-CoV-2-IN-67
SARS-CoV-2-IN-67 (Compound 16), a derivative of vitamin K, exhibits anti-SARS-CoV-2 properties, with an effective concentration (EC50) of 64.8 μM in VeroE6/TMPRSS2 cells, and inhibits SARS-CoV-2 RdRp activity [1].
价 格：￥电议型 号：T81204产 地：中国大陆
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T81203SARS-CoV-2-IN-68；化合物 SARS-CoV-2-IN-68SARS-CoV-2-IN-68
SARS-CoV-2-IN-68 (compound 6C) is a covalent inhibitor of both SARS-CoV-2 PLpro and Mpro, exhibiting potent antiviral properties by targeting the Zn-finger domain of PLpro [1].
价 格：￥电议型 号：T81203产 地：中国大陆
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T81202SARS-CoV-2-IN-69；化合物 SARS-CoV-2-IN-69SARS-CoV-2-IN-69
SARS-CoV-2-IN-69 (Compound 7E) is a potent, non-covalent inhibitor of the SARS-CoV-2 main protease (M^pro) with an EC50 of 7.4 μM and also inhibits the papain-like protease (PL^pro) [1].
价 格：￥电议型 号：T81202产 地：中国大陆
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T81201Sartorypyrone B；化合物 Sartorypyrone BSartorypyrone B
Sartorypyrone B, a 2β-acetoxyl analogue of chevalone C, is derived from the ethyl acetate extract of the culture of Neosartorya tsunodae (KUFC 9213), a fungus associated with marine sponges. This compound demonstrates potent growth inhibitory activity against MCF-7, NCI-H460, and A375-C5 cancer cell lines with GI50 values of 17.8, 20.5, and 25.0 μM, respectively, indicating its potential in the study of breast adenocarcinoma, non-small cell lung cancer, and melanoma [1].
价 格：￥电议型 号：T81201产 地：中国大陆
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T80657SARS-CoV-2 3CLpro-IN-15；化合物 SARS-CoV-2 3CLpro-IN-15SARS-CoV-2 3CLpro-IN-15
SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the identification of potential anti-COVID-19 lead compounds [1].
价 格：￥电议型 号：T80657产 地：中国大陆
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T80636SARS-CoV-2-IN-59；4-(4,5-二氢-2-咪唑基)苯腈SARS-CoV-2-IN-59
SARS-CoV-2-IN-59 (compound E07), an imidazoline derivative, is a non-peptide small molecule that inhibits SARS-CoV-2 by targeting its main protease (Mpro). It exhibits robust binding with Mpro residues (Met 165, Gln 166, Met 165, His 41, Gln 189) [1].
价 格：￥电议型 号：T80636产 地：中国大陆
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T80610Romilkimab；化合物 RomilkimabSAR156597；SAR156597
Romilkimab (SAR156597) is a chimeric humanized immunoglobulin (Ig) antibody designed to specifically target interleukins 4 and 13 (IL-4 and IL-13) [1].
价 格：￥电议型 号：T80610产 地：中国大陆
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T79992Sarglaroids F；化合物 Sarglaroids FSarglaroids F
Sarglaroids F (compound 6), an anti-inflammatory agent extracted from the roots of Grass Coral, suppresses LPS/ATP-induced IL-1β secretion by modulating K+ efflux and diminishing Caspase-1(P20) concentrations. Additionally, Sarglaroids F exhibits no cytotoxic effects on RAW264.7 cells [1].
价 格：￥电议型 号：T79992产 地：中国大陆
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T79677SARS-CoV-2-IN-58；化合物 SARS-CoV-2-IN-58SARS-CoV-2-IN-58
SARS-CoV-2-IN-58 (Compound 21H) serves as an antiviral agent targeting SARS-CoV-2, demonstrating efficacy with an EC50 of 18 μM. It specifically inhibits the SARS-CoV-2 main protease (Mpro) with an IC50 value of 0.35 μM [1].
价 格：￥电议型 号：T79677产 地：中国大陆
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T79676SARS-CoV-2 3CLpro-IN-21；化合物 SARS-CoV-2 3CLpro-IN-21SARS-CoV-2 3CLpro-IN-21
SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 3CL pro with an IC50 of 0.12 μM [1].
价 格：￥电议型 号：T79676产 地：中国大陆
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T79661SARS-CoV-2 3CLpro-IN-18；化合物 SARS-CoV-2 3CLpro-IN-18SARS-CoV-2 3CLpro-IN-18
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent inhibitor of SARS-CoV-2 3CLpro with an IC50 of 0.478 μM. It demonstrates inhibition of SARS-CoV-2 in Vero E6 cells, with an EC50 of 2.499 μM, and exhibits low cytotoxicity (CC50 > 200 μM) [1].
价 格：￥电议型 号：T79661产 地：中国大陆
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T79660SARS-CoV-2 3CLpro-IN-17；化合物 SARS-CoV-2 3CLpro-IN-17SARS-CoV-2 3CLpro-IN-17
Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].
价 格：￥电议型 号：T79660产 地：中国大陆
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T79659SARS-CoV-2 3CLpro-IN-16；SARS-CoV-2 3CLpro 抑制剂16SARS-CoV-2 3CLpro-IN-16
SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.
价 格：￥电议型 号：T79659产 地：中国大陆
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T79570SARS-CoV-2-IN-55；化合物 SARS-CoV-2-IN-55SARS-CoV-2-IN-55
SARS-CoV-2-IN-55 (compound 65) is an inhibitor of SARS-CoV-2 exhibiting low cytotoxicity, characterized by an IC50 of 0.3 μM, effectuated through direct interaction with VSV-S pseudoparticles [1].
价 格：￥电议型 号：T79570产 地：中国大陆
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T79526SARS-CoV-2 nsp14-IN-4；化合物 SARS-CoV-2 nsp14-IN-4SARS-CoV-2 nsp14-IN-4
SARS-CoV-2 nsp14-IN-4 (Compound 12q), a non-cytotoxic and cell-permeable inhibitor of SARS-CoV-2 nsp14 methyltransferase (IC50 = 19 nM), is employed in COVID-19 research [1].
价 格：￥电议型 号：T79526产 地：中国大陆
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T79515SARS-CoV-2 Mpro-IN-10；化合物 SARS-CoV-2 Mpro-IN-10SARS-CoV-2 Mpro-IN-10
SARS-CoV-2 Mpro-IN-10 (27h) is a potent inhibitor of the Mpro enzyme, exhibiting IC50 and EC50 values of 10.9 nM and 43.6 nM, respectively. It is utilized in research focused on the SARS-CoV-2 virus [1].
价 格：￥电议型 号：T79515产 地：中国大陆
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T79462SARS-CoV-2 3CLpro-IN-14；化合物 SARS-CoV-2 3CLpro-IN-14SARS-CoV-2 3CLpro-IN-14
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μM and exhibits minimal cytotoxicity, having a CC50 greater than 50 μM, in Vero E6 cells [1].
价 格：￥电议型 号：T79462产 地：中国大陆
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T79455SARS-CoV-2 Mpro-IN-9；化合物 SARS-CoV-2 Mpro-IN-9SARS-CoV-2 Mpro-IN-9
SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. It effectively suppresses viral replication in SARS-CoV-2-infected Vero E6 cells (EC50 = 1.10 μM) and demonstrates low cytotoxicity (CC50 > 50 μM) [1].
价 格：￥电议型 号：T79455产 地：中国大陆
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T79426SARS-CoV-2-IN-61；化合物 SARS-CoV-2-IN-61SARS-CoV-2-IN-61
SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 ?M and demonstrating antiviral activities [1].
价 格：￥电议型 号：T79426产 地：中国大陆
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T79414SARS-CoV-2-IN-60；化合物 SARS-CoV-2-IN-60SARS-CoV-2-IN-60
SARS-CoV-2-IN-60 (compound 5a) is a specific, irreversible inhibitor of SARS-CoV-2 nsp16-nsp10 methyltransferase, competing with S-adenosylmethionine (SAM) and exhibiting an IC50 of 9 ?M and a Ki of 26 ?M. It binds to a novel pocket near the SAM-binding site on nsp16, suggesting potential as a pan-coronavirus therapeutic [1].
价 格：￥电议型 号：T79414产 地：中国大陆
