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  • T6064UK-383367；化合物UK 383367UK 383367；UK 383367

    UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs.

    价 格：￥电议型 号：T6064产 地：中国大陆

  • T60537ARUK3001185；化合物 ARUK3001185ARUK3001185

    ARUK3001185 (Compound 8l) is a potent, selective, orally active, and brain-penetrant Notum inhibitor(IC50 = 6.7 nM) that is suitable for oral dosing in rodent models of disease [1].

    价 格：￥电议型 号：T60537产 地：中国大陆

  • T6016Maraviroc；马拉维若Celsentri|||UK-427857|||Selzentry；Celsentri|||马拉维若|||UK-427857|||Selzentry

    Maraviroc (Selzentry) is a C-C Chemokine Receptor Type 5 (CCR5) antagonist, and for MIP-1α(IC50=3.3 nM), MIP-1β (IC50=7.2 nM) and RANTES(IC50=5.2 nM).Maraviroc inhibits HIV-1 entry via CCR5 coreceptor interaction.

    价 格：￥电议型 号：T6016产 地：中国大陆

  • T4S0498Glaucocalyxin A；蓝萼甲素Wangzaozin B|||Leukamenin F；蓝萼甲素|||Wangzaozin B|||Leukamenin F

    1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expression of X-linked inhibitor of apoptosis protein. 3. Glaucocalyxin A inhibits Akt phosphorylation, suppresses proliferation, and promotes apoptosis in a dose-dependent manner, but not in normal glial cells. 4. Glaucocalyxin A inhibits collagen-stimulated tyrosine phosphorylation of

    价 格：￥电议型 号：T4S0498产 地：中国大陆

  • T4441UK-5099；化合物UK5099UK 5099|||PF-1005023|||UK5099；UK 5099|||PF-1005023|||UK5099

    UK-5099 (PF-1005023) is an inhibitor of the mitochondrial pyruvate transporter protein MPC. UK-5099 inhibits MPC by covalently and reversibly binding to the C54 of MPC2, which facilitates the transport of pyruvate across the inner mitochondrial membrane. UK-5099 has antitumor activity.

    价 格：￥电议型 号：T4441产 地：中国大陆

  • T41107Kipukasin D；Kipukasin DKipukasin D

    Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.

    价 格：￥电议型 号：T41107产 地：中国大陆

  • T41085UK122UK122UK122

    UK122 is a highly effective and specific inhibitor of urokinase-type plasminogen activator (uPA) with an IC50 value of 0.2 μM. It displays negligible to minimal inhibition towards tissue-type plasminogen activator (tPA), plasmin, thrombin, and trypsin (all IC50 >100 μM). Functioning as a 4-oxazolidinone analogue, UK122 is an anticancer agent that effectively inhibits cancer cell migration and invasion.

    价 格：￥电议型 号：T41085产 地：中国大陆

  • T40870Leukotriene E4；白三烯 E4LTE4；LTE4

    Leukotriene E4 (LTE4) (LTE4) is produced by the action of dipeptidyl peptidase on LTD4 and is a component of the Slow Reactive Substance of Anaphylaxis (SRS-A).LTE4 is present in plasma and urine and can be used to detect asthma.

    价 格：￥电议型 号：T40870产 地：中国大陆

  • T40612Manganese(salen) chloride；化合物Manganese(salen) chlorideEUK-8；EUK-8

    Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.

    价 格：￥电议型 号：T40612产 地：中国大陆

  • T4059Selamectin；塞拉菌素UK-124114；UK-124114|||司拉克丁|||塞拉菌素

    Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.

    价 格：￥电议型 号：T4059产 地：中国大陆

  • T39770UK-59811 hydrochloride；UK-59811 hydrochlorideUK-59811 hydrochloride

    UK-59811 hydrochloride is a potent inhibitor of the Ca V Ab voltage-gated calcium channels in bacterial homotetrameric models. It is derived from Br-dihydropyridine, possessing significant inhibitory properties with an IC 50 of 194 nM.

    价 格：￥电议型 号：T39770产 地：中国大陆

  • T38129Leukotriene F4；Leukotriene F4LTF4；LTF4

    LTF4 is a cysteinyl-leukotriene produced in vitro, but not reported to date in vivo. It is formed by the incubation of LTE4 with γ-glutamyl transpeptidase and glutathione. LTF4 is a weak agonist in its ability to contract vascular smooth muscle. [1] The rank order of potency of the cysteinyl-leukotrienes to contract vascular smooth muscle is LTD4 > LTC4 > LTE4 >> LTF4. [1] [2]

    价 格：￥电议型 号：T38129产 地：中国大陆

  • T38128Leukotriene D4；Leukotriene D4 MaxSpec? StandardLeukotriene D4 MaxSpec? Standard|||LTD4；Leukotriene D

    Leukotriene D4 (LTD4) is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) produced by the metabolism of LTC4 by γ-glutamyl transpeptidase. It is the first cysteinyl-leukotriene metabolite of LTC4 . Like LTC4, LTD4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute hypersensitivity. LTD4 is equipotent to LTC4 in its biological activities, except that LTD4 is nearly 100-fold more effective in the contraction of

    价 格：￥电议型 号：T38128产 地：中国大陆

  • T3808720-hydroxy Leukotriene B4；20-hydroxy Leukotriene B420-hydroxy Leukotriene B4；20-hydroxy Leukotriene

    20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2

    价 格：￥电议型 号：T38087产 地：中国大陆

  • T38062N-acetyl Leukotriene E4；N-acetyl Leukotriene E4N-acetyl Leukotriene E4；N-acetyl Leukotriene E4

    N-acetyl LTE4 is the major inactive metabolite of LTE4 found in bile. This route of metabolism is prominent in the rat, but of minor importance in humans. N-acetyl LTE4 is 100 times less potent than LTC4 as a vasoconstricting agent. In healthy human subjects urinary excretion of N-acetyl LTE4 is about 1.5 nmol/mol creatinine, which is considerably less than that of LTE4 (12 nmol/mol creatinine).

    价 格：￥电议型 号：T38062产 地：中国大陆

  • T37980N-methyl Leukotriene C4；N-methyl Leukotriene C4N-methyl Leukotriene C4；N-methyl Leukotriene C4

    Produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets, leukotriene C4 (LTC4) is the parent cysteinyl leukotriene formed by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4, however, is rapidly metabolized to LTD4 and LTE4, which makes the characterization of LTC4 pharmacology difficult. N-methyl Leukot

    价 格：￥电议型 号：T37980产 地：中国大陆

  • T3797012-epi Leukotriene B4；12-epi Leukotriene B412-epi Leukotriene B4；12-epi Leukotriene B4

    Leukotriene B4 (LTB4) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A4 (LTA4) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA4 is 6-trans-12-epi LTB4. 12-epi LTB4 is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic pr

    价 格：￥电议型 号：T37970产 地：中国大陆

  • T37620Leukotriene C4 methyl ester；Leukotriene C4 methyl esterLeukotriene C4 methyl ester

    Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute all

    价 格：￥电议型 号：T37620产 地：中国大陆

  • T37619Leukotriene B4 Ethanolamide；Leukotriene B4 EthanolamideLeukotriene B4 Ethanolamide

    The effects of Leukotriene B4 (LTB4) are mediated by two known receptors, BLT1 and BLT2. LTB4 is a high affinity ligand for BLT1, and many of its pro-inflammatory effects are believed to be transduced through this receptor. The BLT2 is more enigmatic, in that LTB4 is not a high-affinity ligand, nor is it clear that BLT2 activation promotes inflammation. LTB4 ethanolamide (LTB4-EA) is a theoretical 5-LO metabolite of arachidonoyl ethanolamide (AEA). In CHO cells transfected with human BLTR1, LTB4

    价 格：￥电议型 号：T37619产 地：中国大陆

  • T37618Leukotriene B4 dimethyl amide；Leukotriene B4 dimethyl amideLeukotriene B4 dimethyl amide；Leukotriene

    LTB4 dimethyl amide is a moderate inhibitor of LTB4-induced degranulation of human neutrophils (Ki = 130 nM) and lysozyme release from rat PMNL. LTB4 dimethyl amide appears to be an antagonist of the LTB4 receptor on guinea pig lung membranes.

    价 格：￥电议型 号：T37618产 地：中国大陆

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