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  • T37617Leukotriene B3；Leukotriene B3Leukotriene B3

    LTB3 is the LTA hydrolase metabolite of LTA3 in the leukotriene biosynthetic pathway. LTB3 and LTB4 are equipotent in their pro-inflammatory effects. However, LTB3 is five times less potent than LTB4 in eliciting chemotaxis of human neutrophils.

    价 格：￥电议型 号：T37617产 地：中国大陆

  • T37616Leukotriene A4 methyl ester；Leukotriene A4 methyl esterLeukotriene A4 methyl ester；Leukotriene A4 me

    Leukotriene A4 methyl ester can be converted into leukotriene C4 monomethyl ester catalyzed by the major alkaline cytosolic glutathione transferase in rat liver, which can be used in metabolism-related studies.

    价 格：￥电议型 号：T37616产 地：中国大陆

  • T37615Leukotriene A3 methyl ester；Leukotriene A3 methyl esterLeukotriene A3 methyl ester

    Biosynthesis of LTA3 occurs from 5,8,11-eicosatrienoic acid via the 5-LO pathway and it is the putative intermediate in the biosynthesis of 3-series leukotrienes. LTA3 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed.

    价 格：￥电议型 号：T37615产 地：中国大陆

  • T3749411-trans Leukotriene E4；11-trans Leukotriene E411-trans Leukotriene E4；11-trans Leukotriene E4

    Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.

    价 格：￥电议型 号：T37494产 地：中国大陆

  • T3749311-trans Leukotriene D4；11-trans Leukotriene D411-trans Leukotriene D4；11-trans Leukotriene D4

    11-trans Leukotriene D4 (11-trans LTD4) is a C-11 double bond isomer of LTD4. LTD4 undergoes slow temperature-dependent isomerization to 11-trans LTD4 during storage. 11-trans LTD4 retains about 10-25 % of the potency for contraction of guinea pig ileum, trachea and parenchyma compared to LTD4. It exhibits an ED50 ranging between 12-60 nM for contraction of guinea pig trachea.

    价 格：￥电议型 号：T37493产 地：中国大陆

  • T3749211-trans Leukotriene C4；11-trans Leukotriene C411-trans Leukotriene C4；11-trans Leukotriene C4

    11-trans Leukotriene C4 (11-trans LTC4) is a C-11 double bond isomer of LTC4. LTC4 undergoes slow temperature-dependent isomerization to 11-trans LTC4 during storage. 11-trans LTC4 is produced in smaller amounts relative to LTC4 in ionophore-stimulated HMC-1 cells (a human mast cell line) and equine eosinophils, but not in human neutrophils or RBL-1 cells. It is nearly equipotent with LTC4 for contraction of guinea pig parenchymal and ileum. In a radioligand binding assay using guinea pig ileum

    价 格：￥电议型 号：T37492产 地：中国大陆

  • T37386Dihydro Montelukast；Dihydro MontelukastDihydro Montelukast

    Dihydro montelukast is a potential impurity found in commercial montelukast preparations. Montelukast (sodium salt) is a potent and selective cysteinyl leukotriene 1 (CysLT1) receptor antagonist. Formulations containing montelukast are used for the treatment of asthma as well as for the symptoms associated with allergic rhinitis.

    价 格：￥电议型 号：T37386产 地：中国大陆

  • T3726214,15-Leukotriene E4；14,15-Leukotriene E414,15-Leukotriene E4；14,15-Leukotriene E4

    Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTE4 is a metabolite of 14,15-LTC4 and 14,15-LTD4, an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. These metabolites are classified as eoxins because they are formed mostly by eosinophils

    价 格：￥电议型 号：T37262产 地：中国大陆

  • T3726114,15-Leukotriene D4；14,15-Leukotriene D414,15-Leukotriene D4；14,15-Leukotriene D4

    14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both

    价 格：￥电议型 号：T37261产 地：中国大陆

  • T3726014,15-dehydro Leukotriene B4；14,15-dehydro Leukotriene B414,15-dehydro Leukotriene B4；14,15-dehydro

    Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value

    价 格：￥电议型 号：T37260产 地：中国大陆

  • T3725612-oxo Leukotriene B4；12-oxo Leukotriene B412-oxo Leukotriene B4；12-oxo Leukotriene B4

    Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-LO pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. 12-oxo LTB4 is an initial metabolite of LTB4 formed via the LTB4 12-hydroxydehydrogenase pathway. It is rapidly converted to 10,11-dihydro-12-oxo-LTB4, followed by reduction of the 12-oxo group to give

    价 格：￥电议型 号：T37256产 地：中国大陆

  • T37016Iralukast (CGP 45715A)；Iralukast (CGP 45715A)Iralukast (CGP 45715A)

    Iralukast is a cysteinyl-leukotriene antagonist (CysLT) with a pKi of 7.8 for CysLT1.

    价 格：￥电议型 号：T37016产 地：中国大陆

  • T36808UK 59811 hydrochloride；UK 59811 hydrochlorideUK 59811 hydrochloride

    Blocks CaVAb, a site-directed mutant of bacterial NaVAb with full voltage-dependent Ca2+ channel function (IC50 = 194 nM).

    价 格：￥电议型 号：T36808产 地：中国大陆

  • T36623Antileukinate；AntileukinateAntileukinate

    Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2. It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 μM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits. At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.

    价 格：￥电议型 号：T36623产 地：中国大陆

  • T36423Leukotriene B5；Leukotriene B5Leukotriene B5

    Leukotriene B5 (LTB5) is a leukotriene with diverse biological activities. It is a metabolite of eicosapentaenoic acid formed through the 5-lipoxygenase (5-LO) pathway. LTB5 increases contraction of bullfrog lung strips ex vivo in a concentration-dependent manner.

    价 格：￥电议型 号：T36423产 地：中国大陆

  • T3638Leukadherin-1；化合物Leukadherin-1Leukadherin-1

    Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendothelial migration; reduces inflammation.

    价 格：￥电议型 号：T3638产 地：中国大陆

  • T36061N-Desmethyl Sildenafil；N-去甲基西地那非Desmethylsildenafil|||UK-103,320；Desmethylsildenafil|||UK-103,320

    N-Desmethyl Sildenafil (UK-103,320) (Desmethylsildenafil) is a prominent metabolite of Sildenafil, a potent inhibitor of phosphodiesterase type 5 (PDE5).

    价 格：￥电议型 号：T36061产 地：中国大陆

  • T35457(±)12(13)-DiHOME；(±)12(13)-DiHOME(±)12(13)-DiHOME|||Isoleukotoxin diol；(±)12(13)-DiHOME|||Isoleukoto

    (±)12(13)-DiHOME is the diol form of (±)12(13)-EpOME , a cytochrome P450-derived epoxide of linoleic acid also known as isoleukotoxin. [1] It is formed from 12(13)-EpOME by soluble epoxide hydrolase (sEH) in neutrophils. [2] 12(13)-DiHOME is toxic to Sf21 cells expressing sEH and to lacZ-expressing control cells, unlike isoleukotoxin, which is only toxic to cells containing sEH.[1] [2] Levels of 12(13)-DiHOME are increased in rat spinal cord following burn injury, and it enhances cold tolerance

    价 格：￥电议型 号：T35457产 地：中国大陆

  • T34996Ukrain；化合物 T34996NSC631570|||NSC 631570|||NSC-631570；NSC631570|||NSC 631570|||NSC-631570

    Ukrain, also known as NSC-631570, is claimed to be a semisynthetic compound of thiophosphoric acid (triaziridide) and the alkaloid chelidonine derived from the common weed, Chelidonium majus (greater celandine), which grows primarily in Europe and Asia.

    价 格：￥电议型 号：T34996产 地：中国大陆

  • T34995UK-437719；化合物 T34995UK 437719|||UK437719；UK 437719|||UK437719

    UK-437719 is a bioactive chemical.

    价 格：￥电议型 号：T34995产 地：中国大陆

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