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  • T62142COX-2-IN-17；化合物 COX-2-IN-17COX-2-IN-17

    COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.

    价 格：￥电议型 号：T62142产 地：中国大陆

  • T61429HDAC-IN-33；化合物 HDAC-IN-33HDAC-IN-33

    HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally, HDAC-IN-33 initiates the activation of antitumor immunity [1].

    价 格：￥电议型 号：T61429产 地：中国大陆

  • T614284-PQBH；化合物4-PQBH4-PQBH

    4-PQBH is a potent Nur77-binding agent with antitumour activity.4-PQBH inhibits xenograft tumours through Nur77-mediated endoplasmic stress and autophagy by broadly inducing cysteoaspartase-independent cytoplasmic vacuolisation and parapetaloid ptosis.4-PQBH is used in the study of hepatocellular carcinoma.4-PQBH is a potent Nur77-binding agent with antitumour activity.

    价 格：￥电议型 号：T61428产 地：中国大陆

  • T61427Lamivudine salicylate；化合物 Lamivudine salicylateLamivudine salicylate

    Lamivudine (BCH-189) salicylate is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that effectively inhibits the reverse transcriptase activity of both HIV 1/2 and hepatitis B virus. Moreover, it demonstrates the ability to penetrate the central nervous system [1] [2].

    价 格：￥电议型 号：T61427产 地：中国大陆

  • T61426NOS-IN-2；化合物 NOS-IN-2NOS-IN-2

    NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 μM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for research on inflammatory disorders [1].

    价 格：￥电议型 号：T61426产 地：中国大陆

  • T61425Tyrosinase-IN-5；化合物 Tyrosinase-IN-5Tyrosinase-IN-5

    Tyrosinase-IN-5 (compound 16c) is a highly effective inhibitor of tyrosinase, exhibiting an IC50 value of 0.02 μM. This compound efficiently suppresses melanogenesis while posing minimal toxicity to cells [1].

    价 格：￥电议型 号：T61425产 地：中国大陆

  • T61424OD36 hydrochloride；OD36盐酸盐OD 36 hydrochloride|||OD-36 hydrochloride；OD 36 hydrochloride|||OD-36 hydr

    OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.

    价 格：￥电议型 号：T61424产 地：中国大陆

  • T61423Transthyretin-IN-1；化合物 Transthyretin-IN-1Transthyretin-IN-1

    Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].

    价 格：￥电议型 号：T61423产 地：中国大陆

  • T61422DPP-4-IN-1；化合物 DPP-4-IN-1DPP-4-IN-1

    DPP-4-IN-1 (compound d1) is a highly potent inhibitor of DPP-4 (dipeptidyl peptidase 4) with an IC 50 of 49 nM, making it suitable for diabetes research [1]. It shares structural similarities to Alogliptin and can be effectively utilized for studying diabetes-related mechanisms.

    价 格：￥电议型 号：T61422产 地：中国大陆

  • T61421LUF7244；化合物 LUF7244LUF7244

    LUF7244, a selective allosteric modulator of K v 11.1 channels, effectively suppresses early afterdepolarizations and holds potential for anti-arrhythmia research [1].

    价 格：￥电议型 号：T61421产 地：中国大陆

  • T61420CXCR4 antagonist 6；化合物 CXCR4 antagonist 6CXCR4 antagonist 6

    CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1].

    价 格：￥电议型 号：T61420产 地：中国大陆

  • T6142PD128907 HCl；化合物PD128907盐酸盐PD128907 HCl

    PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.

    价 格：￥电议型 号：T6142产 地：中国大陆

  • T61142Antitubercular agent-17；化合物 Antitubercular agent-17Antitubercular agent-17

    Antitubercular agent-17 (Compound 8a) is an efficacious antitubercular agent, demonstrating Minimum Inhibitory Concentration (MIC) values of 2 μg/ml against M. tuberculosis H37Rv, Spec. 192, and Spec 210, and 128 μg/ml against Spec. 800. It exhibits highly selective antimycobacterial effects [1].

    价 格：￥电议型 号：T61142产 地：中国大陆

  • T58457ACC1；香豆素D1421DEAC|||Coumarin D 1421|||7-(Diethylamino)coumarin-3-carboxylic acid|||D 1421；DEAC|||香豆

    7ACC1 (D 142) selectively affects a single part of the MCT symporter translocation cycle, leading to strict inhibition of lactate influx. This singular activity is associated with antitumor effects less prone to resistance and side effects.

    价 格：￥电议型 号：T5845产 地：中国大陆

  • T5142NAV-2729；化合物NAV-2729NAV-2729

    NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.

    价 格：￥电议型 号：T5142产 地：中国大陆

  • T5138BMS-986142；化合物BMS-986142BMS-986142

    BMS-986142 is a potent and highly selective reversible BTK inhibitor (IC50: 0.5 nM).

    价 格：￥电议型 号：T5138产 地：中国大陆

  • T500142-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one；化合物T500142-methyl-2,3,4,5-tetrahydro-1,5-benzot

    2-methyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one is ligand of CBP.

    价 格：￥电议型 号：T50014产 地：中国大陆

  • T4S1422Praeruptorin E白花前胡素 E白花前胡素 E|||白花前胡素E

    1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activity. 2. Praeruptorin D and E can protect mice from hydrochloric acid (HCl)-induced lung injury by inhibiting polymorphonuclear leukocytes (PMNs) influx, IL-6 release and protein exudation, suggest that they may be useful in the therapy of lung injury.

    价 格：￥电议型 号：T4S1422产 地：中国大陆

  • T4S1421Praeruptorin B(+)-川白芷内酯Praeruptorin D|||(+)-川白芷内酯

    Praeruptorin B is an inhibitor of sterol regulatory element-binding proteins (SREBPs). It can also significantly up-regulate CYP3A4 expression and activity via the PXR-mediated pathway.

    价 格：￥电议型 号：T4S1421产 地：中国大陆

  • T4419UNC2025 2HCl (1429881-91-3(free base))；化合物UNC2025 2HClUNC2025 2HCl (1429881-91-3(free base))

    UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.

    价 格：￥电议型 号：T4419产 地：中国大陆

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