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T4039BIBB 515BIBB 515,Inhibitor,OSC,inhibit,cyclase,effect,metabolism,LDL,BIBB-515,2,3-oxidosqualene,BIBB
BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols. OSC catalyzes the conversion of (3S)-2, 3-oxidosqualene to lanosterol, a precursor to cholesterol, in mammals and fungi. Total cholesterol was reduced by 19% in normolipemic hamsters at a dose of 55 mg/kg/day for 11 days and 25% in hyperlipemic
价 格：￥电议型 号：T4039产 地：中国大陆
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T6734WZ8040HER1,WZ 8040,mutated,WZ8040,Inhibitor,phosphorylation,EGFR,NSCLC,Epidermal growth factor recep
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
价 格：￥电议型 号：T6734产 地：中国大陆
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T9419FesoterodineDesfesoterodine,Fesoterodine,OAB,muscarinic,overactive,Inhibitor,SPM7605,mAChR,orally,5-
Fesoterodine is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).
价 格：￥电议型 号：T9419产 地：中国大陆
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T8737GR 125743h5-HT1B,cognitive disorder,h5-HT1D,cardiovascular,GR-125743,GR125743,inhibit,Parkinson’s di
GR 125743 is a novel antagonist of 5-HT1B/1D receptor.
价 格：￥电议型 号：T8737产 地：中国大陆
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T7417AvatrombopagE 5501,megakaryocytopoiesis,NOD/SCID,mimic,inhibit,TPO,AKR501,Avatrombopag,YM-477,megaka
Avatrombopag is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.
价 格：￥电议型 号：T7417产 地：中国大陆
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T7539O6-Benzylguaninepancreatic,DNA/RNA Synthesis,transcriptional,PARP1,p53,inhibit,cyclin,O-6-Benzylguan
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
价 格：￥电议型 号：T7539产 地：中国大陆
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TQ0027Transcrocetinate disodiumiGluR,Transcrocetinate disodium,Inhibitor,inhibit,Ionotropic glutamate rece
Transcrocetinate disodium, extracted from saffron (Crocus sativus L.), is a high-affinity antagonist of NMDA receptor.
价 格：￥电议型 号：TQ0027产 地：中国大陆
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T9545Compound 1T-0219 (SC)Compound 1T 0219 (SC),Compound 1T0219 (SC)
Compound 1T-0219 (SC) is a blocker of AKT1-FAK interaction reducing the stimulation of FAK phosphorylation in response to extracellular pressure in human SW620 colon cancer cells without affecting basal FAK phosphorylation.
价 格：￥电议型 号：T9545产 地：中国大陆
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T8638NPC 15199NSC334290,NPC-15199,NPC 15199,NPC15199,Fmoc-leucine,inhibit,Inhibitor,NSC 334290,Peroxisome
NPC 15199 is an anti-inflammatory agent.
价 格：￥电议型 号：T8638产 地：中国大陆
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T7130Navarixininhibit,CXC chemokine receptors,Inhibitor,MK 7123,Navarixin,SCH527123,SCH-527123,MK7123,CXC
Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in animal models, characteristics that may be beneficial in the treatment of conditions with unbalanced pulmonary neutrophilia.
价 格：￥电议型 号：T7130产 地：中国大陆
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T6911NSC-87877 disodiumApoptosis,Neuroblastoma,inhibit,Inhibitor,NSC 87877 disodium,PPAR,p53,Phosphatase,
NSC-87877 is a cell-permeable inhibitor of both SHP-1 and SHP-2 with IC50 values of 355 and 318 nM respectively. It also inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation.
价 格：￥电议型 号：T6911产 地：中国大陆
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TN1652Fuscaxanthone Cinhibit,Inhibitor,Fuscaxanthone C
Fuscaxanthone C is a natural product from Garcinia mangostana.
价 格：￥电议型 号：TN1652产 地：中国大陆
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T10696CB2 modulator 1CB2 modulator 1,ischemia,CB-2 modulator 1,osteoporosis,CB2,inflammation,immunedisorde
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.
价 格：￥电议型 号：T10696产 地：中国大陆
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TN2190Scoulerineproliferation,Inhibitor,cancer,Beta-secretase,Scoulerine,Apoptosis,inhibit,microtubule,cyc
Scoulerine is an inhibitor of ?-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.
价 格：￥电议型 号：TN2190产 地：中国大陆
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T94734SC-203tumor,antineoplastic,Fms like tyrosine kinase 3,Vascular endothelial growth factor receptor,4
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs).
价 格：￥电议型 号：T9473产 地：中国大陆
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T9108BI-0115inhibit,BI-0115,LOX-1,atherosclerosis,BI0115,BI 0115,oxLDL binding,Inhibitor
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of the homodimeric ligand binding domain. The structure of LOX-1 bound to BI-0115 shows that inter-ligand interactions at the receptor interfaces are key to the formation of the receptor tetramer thereby blocking oxLDL binding.
价 格：￥电议型 号：T9108产 地：中国大陆
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T8732CTPI-2macrophage,carrier,CTPI-2,NSCLC,transporter,glucose,steatohepatitis,CTPI 2,Mitochondrial Metab
CTPI-2 is an inhibitor of mitochondrial citrate carrier SLC25A1 with(KD : 3.5 μM). CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 exhibits anti-tumor activity.CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet.
价 格：￥电议型 号：T8732产 地：中国大陆
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T9724WAY-340935Inhibitor,WAY340935,Vascular endothelial growth factor receptor,WAY 340935,inhibit,VEGFR,A
WAY-340935 has anti-inflammatory and analgesic activities.
价 格：￥电议型 号：T9724产 地：中国大陆
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T7405Piperidolateinhibit,Muscarinic acetylcholine receptor,Piperidolate,mAChR,Inhibitor
Piperidolate inhibits intestinal cramp induced by acetylcholine
价 格：￥电议型 号：T7405产 地：中国大陆
