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T5317CridanimodCridanimod,10-carboxymethyl-9-acridanone,XBIO-101
Cridanimod (10-carboxymethyl-9-acridanone, CMA) is a potent STING agonist that directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route.
价 格:¥电议型 号:T5317产 地:美洲
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T5347CXD-101CXD-101
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101 has no activity against HDAC class II
价 格:¥电议型 号:T5347产 地:美洲
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T5449BamaquimastBamaquimast,F 10126,L 0042
Bamaquimast is an inhibitor of proton pump
价 格:¥电议型 号:T5449产 地:美洲
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T5995LarotrectinibLarotrectinib,LOXO-101,ARRY-470
Larotrectinib is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).
价 格:¥电议型 号:T5995产 地:美洲
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T6101EntospletinibEntospletinib,GS-9973,
Entospletinib (IC50= 7.7 nM)is a specific Syk inhibitor,which is orally bioavailable.
价 格:¥电议型 号:T6101产 地:美洲
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T6194FidaxomicinFidaxomicin,PAR-101,OPT-80
Fidaxomicin is a semisynthetic macrolide antibiotic used to treat Clostridium difficile-associated diarrhea in adults. Fidaxomicin has minimal systemic absorption and has not been linked to serum enzyme elevations during therapy or to instances of clinica
价 格:¥电议型 号:T6194产 地:美洲
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T6396AT101 acetateAT101 acetate,(-)-Gossypol acetic acid,(R)-Gossypol acetic acid
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32 μM, 0.48 μM and 0.18 μM; does not inhibit BIR3 domain and BID. Phase 2.
价 格:¥电议型 号:T6396产 地:美洲
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T8827EMAC10101d;化合物EMAC10101dEMAC10101d
compound EMAC10101d, bearing a 2,4-dichorophenyl substituent in position 4 of the dihydrothiazole ring, was the most potent and selective toward hCA II with an inhibitory activity in the low nanomolar range.
价 格:¥电议型 号:T8827产 地:中国大陆
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T8806Fluzoparib;氟唑帕利HS10160|||SHR3162;HS10160|||SHR3162|||氟唑帕利
Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.
价 格:¥电议型 号:T8806产 地:中国大陆
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T8758Poziotinib hydrochloride;波齐替尼盐酸盐HM 781-36B hydrochloride|||NOV120101 hydrochloride;HM 781-36B hydroc
Poziotinib hydrochloride irreversibly inhibits EGFR (HER1 or ErbB1), including EGFR mutants, HER2, and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. It is an orally bioavailable, quinazoline-based pan epidermal growth factor receptor (EGFR or HER) inhibitor with potential antineoplastic activity.
价 格:¥电议型 号:T8758产 地:中国大陆
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T8651CAL-101;化合物CAL-101(S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one|||GS-110
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than C2β, hVPS34, DNA-PK and mTOR.
价 格:¥电议型 号:T8651产 地:中国大陆
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T8550NDMC101;化合物NDMC101NDMC101
NDMC101 is an inhibitor of dipeptidyl peptidase-IV activity in human T cells and exhibits immunomodulatory effects. It also acts as a novel inhibitor of NFATc1 and NF-κB activity.
价 格:¥电议型 号:T8550产 地:中国大陆
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T8544Masitinib mesylate;甲磺酸马赛替尼AB-1010 mesylate;甲磺酸马赛替尼|||AB-1010 mesylate|||马赛替尼
Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;PDGFRα/β;LynB,respectively).
价 格:¥电议型 号:T8544产 地:中国大陆
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T8517Belinostat;贝利司他PX105684|||PXD101|||PXD-101;PX105684|||PXD101|||贝利司他|||PXD-101
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
价 格:¥电议型 号:T8517产 地:中国大陆
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T8448ZSET1446;化合物ZSET-1446ZSET-1446|||ST-101;ZSET-1446|||ST-101
ZSET1446 (ST-101) is a T-type calcium channel activator potentially for the treatment of learning deficits in various types of Alzheimer disease (AD) models.
价 格:¥电议型 号:T8448产 地:中国大陆
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T83962C 101248;化合物 C 101248C 101248
C 101248 is a selective and potent inhibitor targeting both mouse and human tandem pore domain halothane-inhibited K+ channel 1 (THIK-1, IC50= 50 nM), without affecting the K2P family members (TREK-1, TWIK-2) and Kv2.1. This compound effectively blocks tonic and ATP-evoked THIK-1 K+ currents as observed in whole-cell patch-clamp recordings of mouse hippocampal microglia. Additionally, C 101248 mitigates neuroinflammation by inhibiting the NLRP3-dependent release of IL-1β in isolated microglia.
价 格:¥电议型 号:T83962产 地:中国大陆
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T83685UFP101 TFA;化合物 UFP101 TFAUFP101 TFA
UFP101 is a synthetic peptide that functions as an antagonist of the nociceptin receptor, demonstrating high affinity with a Ki of 0.06 nM in CHO cells expressing the human receptor. It exhibits selectivity for the nociceptin receptor over the κ-opioid receptor, with a Ki of 204 nM in CHO cells expressing the rat receptor. The compound effectively inhibits GTPγS release from the nociceptin receptor in CHO cell membranes, with an EC50 of 1.86 nM. When administered intracerebroventricularly at a d
价 格:¥电议型 号:T83685产 地:中国大陆
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T83101Antibacterial agent 160;化合物 Antibacterial agent 160Antibacterial agent 160
Antibacterial Agent 160 is a potent antibacterial agent that rapidly eradicates bacteria and inhibits the formation of bacterial biofilms. It disrupts the normal functioning of DNA, resulting in cellular death [1].
价 格:¥电议型 号:T83101产 地:中国大陆
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T83095Anticancer agent 101;化合物 Anticancer agent 101Anticancer agent 101
Anticancer Agent 101, a tetracaine derivative, exhibits anti-cancer activity [1].
价 格:¥电议型 号:T83095产 地:中国大陆
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T8216T-1101 tosylate;化合物T-1101 tosylateTAI-95 tosylate;TAI-95 tosylate
T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.
价 格:¥电议型 号:T8216产 地:中国大陆