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T18477NAMPT inhibitor-linker 1；化合物 T18477NAMPT inhibitor-linker 1
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.
价 格：￥电议型 号：T18477产 地：中国大陆
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T18277Mal-PEG2-oxyamine；化合物 T18277Mal-PEG2-oxyamine
Mal-PEG2-oxyamine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18277产 地：中国大陆
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T18177m-PEG3-amido-C3-triethoxysilane；化合物 T18177m-PEG3-amido-C3-triethoxysilane
m-PEG3-amido-C3-triethoxysilane is a polyethylene glycol (PEG)-based linker commonly utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
价 格：￥电议型 号：T18177产 地：中国大陆
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T1808kb-NB77-78；化合物kb-NB77-78kb-NB77-78
kb-NB77-78 is an analog of CID797718, which is a by-product of the synthesis of the parental compound, CID755673(PKD1 inhibitor).
价 格：￥电议型 号：T1808产 地：中国大陆
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T18077m-PEG-acrylate (MW 10000)；化合物 T18077m-PEG-acrylate (MW 10000)
m-PEG-acrylate (MW 10000) is a polyethylene glycol (PEG)-based linker utilized for the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
价 格：￥电议型 号：T18077产 地：中国大陆
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T17977Fmoc-PEA；化合物Fmoc-PEAFmoc-PEA
Fmoc-PEA (Example 1-2) is a used as a cleavable linker for antibody-drug conjugates (ADC).
价 格：￥电议型 号：T17977产 地：中国大陆
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T17877VH032-cyclopropane-F；化合物T17877VHL ligand 3|||E3 ligase Ligand 19|||Phenolic VH101；VHL ligand 3|||E3
VH032-cyclopropane-F (Phenolic VH101) is a VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein by a linker to form PROTACs. PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4.
价 格：￥电议型 号：T17877产 地：中国大陆
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T17799DBCO-PEG4-SS-TCO；化合物 T17799DBCO-PEG4-SS-TCO
DBCO-PEG4-SS-TCO is a cleavable 4-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs)[1]. It plays a crucial role in connecting the drug payload to the antibody, enabling targeted drug delivery.
价 格：￥电议型 号：T17799产 地：中国大陆
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T17798DBCO-PEG4-PFP ester；化合物 T17798DBCO-PEG4-PFP ester
DBCO-PEG4-PFP ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T17798产 地：中国大陆
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T17797DBCO-PEG4-NH-Boc；化合物 T17797DBCO-PEG4-NH-Boc
DBCO-PEG4-NH-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T17797产 地：中国大陆
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T17796DBCO-PEG4-Desthiobiotin；化合物 T17796DBCO-PEG4-Desthiobiotin
DBCO-PEG4-Desthiobiotin is a polyethylene glycol (PEG) derivative utilized as a linker for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].
价 格：￥电议型 号：T17796产 地：中国大陆
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T17795DBCO-PEG4-alkyne；化合物 T17795DBCO-PEG4-alkyne
DBCO-PEG4-alkyne is a four-unit PEG linker with non-cleavable properties, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T17795产 地：中国大陆
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T17794DBCO-PEG4-alcohol；化合物 T17794DBCO-PEG4-alcohol
DBCO-PEG4-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T17794产 地：中国大陆
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T17793DBCO-PEG4-Ahx-DM1；化合物 T17793DBCO-PEG4-Ahx-DM1
DBCO-PEG4-Ahx-DM1 is a drug-linker conjugate that combines the microtubulin inhibitor DM1 (mertansine), which is an antibody-conjugatable maytansinoid designed to reduce systemic toxicity and improve tumor-specific delivery, with the linker DBCO-PEG4-Ahx, for the development of antibody drug conjugates (ADCs).
价 格：￥电议型 号：T17793产 地：中国大陆
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T17792DBCO-PEG3-TCO；化合物 T17792DBCO-PEG3-TCO
DBCO-PEG3-TCO is a non-cleavable three-unit polyethylene glycol (PEG) linker employed for synthesizing antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T17792产 地：中国大陆
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T17791DBCO-PEG3-NHS ester；DBCO-PEG3-NHS酯DBCO-PEG3-NHS ester
DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.
价 格：￥电议型 号：T17791产 地：中国大陆
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T17790DBCO-PEG3-oxyamine；化合物 T17790DBCO-PEG3-oxyamine
DBCO-PEG3-oxyamine is a non-cleavable 3-unit polyethylene glycol linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T17790产 地：中国大陆
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T1779SAG；化合物Smoothened AgonistSmoothened Agonist (SAG) HCl|||Smoothened Agonist；Smoothened Agonist (SAG)
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.
价 格：￥电议型 号：T1779产 地：中国大陆
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T17789DBCO-(PEG2-VC-PAB-MMAE)2；化合物 T17789DBCO-(PEG-2-VC-PAB-MMAE)2|||DBCO(PEG2VCPABMMAE)2|||DBCO-(PEG2-VC-
DBCO-(PEG2-VC-PAB-MMAE)2 consists of Monomethyl auristatin E (MMAE), a toxin payload in antibody-drug conjugate [1], conjugated to the cleavable linker DBCO-(PEG2-VC-PAB)2. MMAE, a potent tubulin inhibitor, serves as the cytotoxic component in this formulation.
价 格：￥电议型 号：T17789产 地：中国大陆
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T17788DBCO-(PEG2-Val-Cit-PAB)2；化合物 T17788DBCO-(PEG2-Val-Cit-PAB)2
DBCO-(PEG2-Val-Cit-PAB)2 is a dual cleavable ADC linker for antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T17788产 地：中国大陆
