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T3S2105N-Benzylpalmitamide；N-苄基十六烷酰胺Macamide 1|||N-Benzylhexadecanamide；Macamide 1|||玛卡酰胺 B|||N-苄基十六烷酰胺|||N
N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders.
价 格：￥电议型 号：T3S2105产 地：中国大陆
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T39418Leptin (93-105), human；Leptin (93-105), humanLeptin (93-105), human
Leptin (93-105), human, refers to the peptide fragment consisting of amino acids 93 to 105 from the human leptin protein. Leptin is a peptide hormone comprising 167 amino acids, predominantly synthesized by adipocytes. Its primary function involves coordinating metabolic adaptations to fasting within the central nervous system.
价 格：￥电议型 号：T39418产 地：中国大陆
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T39290FF-10502；FF-10502FF-10502
FF-10502 is a pyrimidine nucleoside antimetabolite and a structural analog of Gemcitabine. This compound effectively inhibits DNA polymerase α and β, demonstrating potent anticancer activity by targeting dormant cells.
价 格：￥电议型 号：T39290产 地：中国大陆
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T39130Elsubrutinib；ElsubrutinibABBV-105；ABBV-105
Elsubrutinib (ABBV-105) is a highly active, potent, and selective orally-administered inhibitor of Bruton´s tyrosine kinase (BTK). It irreversibly inhibits the catalytic domain of BTK with an IC50 value of 0.18 μM. Elsubrutinib holds potential for the advancement of research on inflammatory diseases.
价 格：￥电议型 号：T39130产 地：中国大陆
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T39105Ibiglustat succinateIbiglustat succinateGZ402671succinate|||Venglustat succinate|||Ibiglustat succin
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS). It is utilized in the investigation of Gaucher disease type 3, Parkinson´s disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
价 格：￥电议型 号：T39105产 地：中国大陆
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T38692Fabesetron法贝司琼法贝司琼|||FK1052 free base
Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms.
价 格：￥电议型 号：T38692产 地：中国大陆
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T38365CAY10597；CAY10597CAY10597
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the
价 格：￥电议型 号：T38365产 地：中国大陆
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T38105Ixekizumab；伊西贝单抗LY2439821；LY2439821
Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A with a Kd value of <3 pM.Ixekizumab blocks the binding of IL-17A to IL-17RA but not to other IL-17 family members.Ixekizumab is used for the treatment of moderate to severe plaque psoriasis, psoriasis, arthritis and psoriasis. arthritis, and psoriasis.
价 格：￥电议型 号：T38105产 地：中国大陆
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T38097Antibiotic PF 1052；Antibiotic PF 1052Antibiotic PF 1052
Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in
价 格：￥电议型 号：T38097产 地：中国大陆
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T37830CAY10599CAY10599CAY-10599|||CAY10599
CAY10599 has a wide range of applications in life science related research.
价 格：￥电议型 号：T37830产 地：中国大陆
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T37829CAY10573CAY10573CAY-10573|||CAY10573
The peroxisome proliferator-activated receptors (PPARs) are lipid-activated transcription factors often used as drug targets for the treatment of metabolic disorders. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It potently transactivates PPARα, γ, and δ with EC50 values of 8, 70, and 500 nM, respectively. CAY10573 demonstrates stronger binding and functional activity for PPARγ than the antidiabetic compound ros
价 格：￥电议型 号：T37829产 地：中国大陆
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T37828CAY10514CAY10514CAY-10514|||CAY10514
CAY10514 is an aromatic analog of 8(S)-HETE. It acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively.
价 格：￥电议型 号：T37828产 地：中国大陆
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T37827CAY10506；CAY10506CAY10506；CAY10506
Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM.
价 格：￥电议型 号：T37827产 地：中国大陆
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T37670CAY10568；CAY10568CAY10568
Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists sh
价 格：￥电议型 号：T37670产 地：中国大陆
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T37556CAY10502；CAY10502CAY10502
Phospholipase A2 (PLA2) catalyzes the hydrolysis of phospholipids at the sn-2 position leading to the production of lysophospholipids and free fatty acids. Calcium-dependent cytosolic PLA2 (cPLA2α) is a 85 kDa enzyme that plays a key role in the arachidonic cascade and the inflammatory response associated with this metabolic pathway. CAY10502 is a potent inhibitor of calcium-dependent cytosolic PLA2α (cPLA2α) with an IC50 value of 4.3 nM for the purified enzyme from human platelets. It inhibits
价 格：￥电议型 号：T37556产 地：中国大陆
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T36964BML-259；化合物BML-259CAY10554；CAY10554
BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.
价 格：￥电议型 号：T36964产 地：中国大陆
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T36963CAY10503CAY10503CAY-10503|||CAY10503
CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 μM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 μM CAY10503, whereas 10 μM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the follo
价 格：￥电议型 号：T36963产 地：中国大陆
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T36672CAY10561；CAY10561CAY10561
The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561
价 格：￥电议型 号：T36672产 地：中国大陆
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T36550CAY10535CAY10535CAY10535|||CAY-10535
TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for
价 格：￥电议型 号：T36550产 地：中国大陆
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T36105coumarin-SAHA；coumarin-SAHAcoumarin-SAHA|||coumarin-SAHA|||coumarin SAHA|||coumarinSAHA|||coumarin-S
Suberoylanilide hydroxamic acid (SAHA) is a class I and class II histone deacetylase (HDAC) inhibitor that binds directly to the catalytic site of the enzyme thereby blocking substrate access. [1] coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. [2] The fluorescence excitation and emission maxima of free c-SAHA is 325 and 400 nm
价 格：￥电议型 号：T36105产 地：中国大陆
