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T72886Akt1&PKA-IN-2;化合物 Akt1&PKA-IN-2Akt1&PKA-IN-2
Akt1&PKA-IN-2 ((R)-29), a compound with specificity towards PKB/AKT and notable selectivity for cyclin-dependent kinase 2 (CDK2), effectively inhibits AKT1, PKAa, and CDK2a with IC50 values of 0.007 ?M, 0.01 ?M, and 0.69 ?M, respectively.
价 格:¥电议型 号:T72886产 地:中国大陆
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T72885Akt1&PKA-IN-1;化合物 Akt1&PKA-IN-1Akt1&PKA-IN-1
Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).
价 格:¥电议型 号:T72885产 地:中国大陆
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T72682Lankacyclinone C;化合物 Lankacyclinone CLankacyclinone C
Lankacyclinone C, a congener of lankacidin C devoid of the δ-lactone moiety, exhibits antitumor activity.
价 格:¥电议型 号:T72682产 地:中国大陆
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T72624Kallikrein 5-IN-2;化合物 Kallikrein 5-IN-2Kallikrein 5-IN-2
Kallikrein 5-IN-2 is a potent inhibitor of Kallikrein KLK5, exhibiting selectivity with a pIC50 value of 7.1. By inhibiting KLK5, it has the potential to normalize epidermal shedding, thereby reducing associated inflammation and itching.
价 格:¥电议型 号:T72624产 地:中国大陆
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T72337Plasma kallikrein-IN-2;化合物 Plasma kallikrein-IN-2Plasma kallikrein-IN-2
Plasma kallikrein-IN-2, a potent inhibitor of plasma kallikrein (PKal) with an inhibitory concentration (IC) 50 value of 0.1 nM, is utilized in research targeting hereditary angioedema, diabetic macular edema, and diabetic retinopathy.
价 格:¥电议型 号:T72337产 地:中国大陆
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T72145Montelukast dicyclohexylamine;化合物 Montelukast dicyclohexylamineMK0476 dicyclohexylamine;MK0476 dicyc
Montelukast dicyclohexylamine (MK0476), a potent, selective, and orally active antagonist of the cysteinyl leukotriene receptor 1 (CysLT1), is utilized in the research of asthma, liver injury, and COVID-19. It exhibits antioxidant properties in the context of intestinal ischemia-reperfusion injury and can mitigate cardiac damage. Additionally, it reduces eosinophil infiltration in the airways of asthmatic patients.
价 格:¥电议型 号:T72145产 地:中国大陆
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T71929Clamikalant;化合物 ClamikalantClamikalant
Clamikalant inhibits ATP-sensitive potassium channel.
价 格:¥电议型 号:T71929产 地:中国大陆
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T71784Asukamycin;化合物 AsukamycinAsukamycin
Asukamycin is polyketide isolated from the S. nodosus subspecies asukaensis that demonstrates a broad range of antibiotic functions. It has been shown to inhibit growth of various tumor cell lines by activating caspases 8 and 3.
价 格:¥电议型 号:T71784产 地:中国大陆
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T71551KAI-1678;化合物 KAI-1678KAI-1678
KAI-1678 is an inhibitor of epsilon protein kinase C (εPKC). KAI-1678 is effective in the treatment of postoperative pain following total hip or total knee replacement.
价 格:¥电议型 号:T71551产 地:中国大陆
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T71505KAL-21404358;化合物 KAL-21404358KAL-21404358
KAL-21404358 is a Novel allosteric inhibitor of K-RasG12D, binding to the P110 site of K-RasG12D, impairing the K-RasG12D interaction with B-Raf, and disrupting the RAF-MEK-ERK and the PI3K-AKT signaling pathway.
价 格:¥电议型 号:T71505产 地:中国大陆
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T71480Kahweol linoleate;化合物 Kahweol linoleateKahweol linoleate
Kahweol linoleate is a semi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
价 格:¥电议型 号:T71480产 地:中国大陆
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T71479Kahweol oleate;化合物 Kahweol oleateKahweol oleate
Kahweol oleate is emi-syntetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1 induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
价 格:¥电议型 号:T71479产 地:中国大陆
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T71478Kahweol stearate;化合物 Kahweol stearateKahweol stearate
Kahweol stearate is a semi-synthetic derivative of kahweol, a natural product found in coffee beans. It exhibits a wide variety of biological activities, including inhibiting RANKL-induced osteoclast generation, inducing cell cycle arrest and apoptosis in oral squamous cell carcinoma cells, preventing aflatoxin B1-induced DNA adduct formation, and suppressing H2O2-induced DNA damage and oxidative stress.
价 格:¥电议型 号:T71478产 地:中国大陆
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T71446Kalafungin;化合物 KalafunginKalafungin
Kalafungin antimicrobial agent that is inhibitory in vitro against a variety of pathogenic fungi, yeasts, protozoa, gram-positive bacteria, and, to a lesser extent, gram-negative bacteria.
价 格:¥电议型 号:T71446产 地:中国大陆
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T71369Montelukast sulfoxide;化合物 Montelukast sulfoxideMontelukast sulfoxide
Montelukast sulfoxide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
价 格:¥电议型 号:T71369产 地:中国大陆
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T71152Montelukast bis-sulfide;化合物 Montelukast bis-sulfideMontelukast bis-sulfide
Montelukast bis-sulfide is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.
价 格:¥电议型 号:T71152产 地:中国大陆
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T70592Makaluvamine A;化合物 Makaluvamine AMakaluvamine A
Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.
价 格:¥电议型 号:T70592产 地:中国大陆
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T70549Kadsurenin L;化合物 Kadsurenin LKadsurenin L
Kadsurenin L is a neolignan originally isolated from Piper kadsura. It has a role as a platelet-activating factor receptor antagonist and a plant metabolite.
价 格:¥电议型 号:T70549产 地:中国大陆
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T70540Pinokalant;化合物PinokalantLOE-908;LOE-908
Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region, and reduces the size of the lesion on magnetic resonance images in the acute phase after middle cerebral artery occlusion in rats.Pinokalant is a potential SARS-CoV-2 protease inhibitor for the study of stroke.
价 格:¥电议型 号:T70540产 地:中国大陆
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T70507KAI-407;化合物 KAI-407KAI-407
KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compou
价 格:¥电议型 号:T70507产 地:中国大陆