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  • T79984Chaparrinone；化合物 ChaparrinoneChaparrinone

    Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL against Plasmodium falciparum and 0.34 μg/mL against P-388 cells [1] [2].

    价 格：￥电议型 号：T79984产 地：中国大陆

  • T79971Asparanin A；化合物 Asparanin AAsparanin A

    Asparanin A, an apoptosis inducer with anticancer properties, arrests the cell cycle in the G0/G1 phase via the mitochondria and PI3K/AKT signaling pathways. It effectively inhibits cancer cell proliferation and has shown in vivo efficacy in a mouse xenograft model of Ishikawa endometrial carcinoma, significantly reducing tumor growth [1].

    价 格：￥电议型 号：T79971产 地：中国大陆

  • T79853Lerzeparib；化合物 LerzeparibLerzeparib

    Lerzeparib is a PARP (ADP-ribose polymerase) inhibitor that exhibits antineoplastic activity [1].

    价 格：￥电议型 号：T79853产 地：中国大陆

  • T79678PPARγ-IN-2；化合物 PPARγ-IN-2PPARγ-IN-2

    "PPARγ-IN-2 (Compound 5a), a PPARγ inhibitor, exhibits an EC50 of 0.106 μM in inhibiting TG accumulation in 3T3-L1 preadipocytes. Furthermore, PPARγ-IN-2 counteracts obesity and associated metabolic syndrome induced by a high-fat cholesterol (HFC) diet and diminishes lipid accumulation in adipose tissue [1]."

    价 格：￥电议型 号：T79678产 地：中国大陆

  • T79647VEGFR/PARP-IN-1；化合物 VEGFR/PARP-IN-1VEGFR/PARP-IN-1

    VEGFR/PARP-IN-1 (Compound 14b) is a dual inhibitor of VEGFR and PARP with IC50 values of 191 nM and 60.9 nM, respectively. It impairs DNA damage repair pathways, promotes apoptosis, and halts cells in the G2/M phase. This compound demonstrates considerable antiproliferative activity against BRCA wild-type breast cancer cells, with IC50 values of 4.1 μM for MDA-MB-231 cells and 3.5 μM for MCF-7 cells, indicating its potential as an antitumor and anti-metastasis agent [1].

    价 格：￥电议型 号：T79647产 地：中国大陆

  • T79593PARP1-IN-14；化合物 PARP1-IN-14PARP1-IN-14

    PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 ?/?) and Capan-1 (BRCA2 ?/?) cells, with IC50 values under 0.3 nM [1].

    价 格：￥电议型 号：T79593产 地：中国大陆

  • T79415Antiparasitic agent-18；化合物 Antiparasitic agent-18Antiparasitic agent-18

    Antiparasitic agent-18 (compound 3a) exhibits potent and selective antiprotozoal activity, demonstrating effective inhibition of T. brucei (EC 50 =0.4 ?M), T. cruzi (EC 50 =0.21 ?M), and L. donovani (EC 50 =0.26 ?M) [1].

    价 格：￥电议型 号：T79415产 地：中国大陆

  • T79405PARP1-IN-15；化合物 PARP1-IN-15PARP1-IN-15

    PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer (TNBC) cells and patient-derived organoids, making it useful for TNBC research, including cases with or without BRCA1 mutations [1].

    价 格：￥电议型 号：T79405产 地：中国大陆

  • T79330PARP-1-IN-13；化合物 PARP-1-IN-13PARP-1-IN-13

    PARP-1-IN-13 (Compound 19c) is a potent PARP-1 inhibitor with an IC50 of 26 nM, hindering DNA single-strand break repair and exacerbating DNA double-strand breaks. It induces apoptosis in cancer cells via the mitochondrial pathway [1].

    价 格：￥电议型 号：T79330产 地：中国大陆

  • T7929L-Aspartic Acid 4-Benzyl Ester；L-天冬氨酸-4-苄酯L-Aspartic Acid 4-Benzyl Ester

    L-Aspartic Acid 4-Benzyl Ester is a chelating agent that forms stable complexes with metal ions. It has been used to study the effect of metal ions on enzyme activity and to investigate the role of metal ions in the regulation of gene expression.

    价 格：￥电议型 号：T7929产 地：中国大陆

  • T79182PPARγ agonist 8；化合物 PPARγ agonist 8PPARγ agonist 8

    PPARγ agonist 8, a compound that acts on the peroxisome proliferator-activated receptor gamma (PPARγ), has been shown to stimulate peroxisome proliferator response element (PPRE)-luciferase activity with an effective concentration (EC50) of 0.2 μM [1].

    价 格：￥电议型 号：T79182产 地：中国大陆

  • T78966Antiparasitic agent-17；化合物 Antiparasitic agent-17Antiparasitic agent-17

    Antiparasitic Agent-17 (compound 5u), an orally active antiparasitic, demonstrates inhibition against both Chloroquine-sensitive (Pf3D7) and Chloroquine-resistant (PfK1) strains, with IC50 values of 0.96 μM and 1.67 μM, respectively [1].

    价 格：￥电议型 号：T78966产 地：中国大陆

  • T78806PPARδ agonist 9；化合物 PPARδ agonist 9PPARδ agonist 9

    PPARδ agonist 9 (compound 21), with an EC50 of 3.6 nM, is effective in vivo, decreasing serum MCP-1 concentrations in mice and markedly reducing atherosclerotic development in the LDLr-KO model with an inhibition rate of 50-60% [1].

    价 格：￥电议型 号：T78806产 地：中国大陆

  • T78787PARP-1/2-IN-2；化合物 PARP-1/2-IN-2PARP-1/2-IN-2

    PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].

    价 格：￥电议型 号：T78787产 地：中国大陆

  • T7853(+)-Sparteine(+)-鹰爪豆碱鹰爪豆碱|||(+)-鹰爪豆碱|||Pachycarpine

    (+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent

    价 格：￥电议型 号：T7853产 地：中国大陆

  • T78521Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE；化合物 Mc-Alanyl-Alanyl-Asparagine-PAB-MMAEMc-Alanyl-Alanyl-Aspara

    Compound S6, Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE, is a potent anticancer agent specifically activated by the tumor microenvironment; it demonstrates efficacy in suppressing tumor growth in mice[1].

    价 格：￥电议型 号：T78521产 地：中国大陆

  • T78470β-Aspartylaspartic acid；化合物 β-Aspartylaspartic acidL-β-Aspartyl-L-aspartic acid；L-β-Aspartyl-L-aspar

    β-Aspartylaspartic acid, a natural compound, is found in the shoots of Asparagus officinalis [1].

    价 格：￥电议型 号：T78470产 地：中国大陆

  • T78246Lemzoparlimab；来佐利单抗TJC4|||TJ011133；TJC4|||TJ011133

    Lemzoparlimab (TJ011133; TJC4), a humanized anti-CD47 IgG4 antibody, exhibits potent antitumor activity [1].

    价 格：￥电议型 号：T78246产 地：中国大陆

  • T78182PARP-1-IN-4；PARP-1抑制剂4PARP-1-IN-4

    PARP-1-IN-4 is a potent PARP-1 inhibitor with potential see anti-tumor activity, and inhibition of PARP-1 may be used in cancer development.

    价 格：￥电议型 号：T78182产 地：中国大陆

  • T78157PARP-1-IN-3；PARP-1抑制剂13PARP-1-IN-3

    PARP-1-IN-3 is a potent PARP-1 inhibitor that inhibits PARP-1 and PARP-2 with IC50 values of 0.25 nM and 2.34 nM, respectively.PARP-1-IN-3 has potential anti-inflammatory activity, induces apoptosis, and arrests the cell cycle in the G2/M phase.PARP-1-IN-3 may be useful for the study of cancer-related diseases. cancer-related diseases.

    价 格：￥电议型 号：T78157产 地：中国大陆

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