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T15579INDY;化合物INDY1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one;1-(3-ethyl-5-hydroxy-1,3-be
INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.
价 格:¥电议型 号:T15579产 地:中国大陆
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T15503HQL-79;化合物 T15503HQL-79
HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS.
价 格:¥电议型 号:T15503产 地:中国大陆
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T15479HFI-142;化合物 T15479HFI-142
HFI-142 is an inhibitor of insulin-regulated aminopeptidase (IRAP) (Ki: 2.01 μM).
价 格:¥电议型 号:T15479产 地:中国大陆
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T15463(Rac)-HAMI 3379;化合物 T15463HAMI 3379;HAMI 3379
HAMI 3379 is a potent and selective antagonist of the Cysteinyl leukotriene (CysLT2) receptor. HAMI 3379 has a protective effect on acute and subacute ischemic brain injury. It also attenuates microglia-related inflammation.
价 格:¥电议型 号:T15463产 地:中国大陆
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T15457LH-Lys-Trp-Lys-OH acetate;化合物 H-Lys-Trp-Lys-OH acetateH-Lys-Trp-Lys-OH acetate(38579-27-0 free base);
H-Lys-Trp-Lys-OH acetate is a peptide with antibacterial and antiviral activities.
价 格:¥电议型 号:T15457L产 地:中国大陆
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T15455RGH-5526;化合物 T15455GYKI-11679;GYKI-11679
RGH-5526 is a novel antihypertensive drug. It causes an increase in hypothalamic norepinephrine (NA) turnover (utilization), and the increase in hypothalamic noradrenergic neuron activity may lead to a decrease in peripheral sympathetic nerve activity, resulting in a significant reduction in blood pressure.
价 格:¥电议型 号:T15455产 地:中国大陆
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T15439GSK3395879;化合物 T15439GSK3395879
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
价 格:¥电议型 号:T15439产 地:中国大陆
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T15434GSK2798745;化合物 T15434GSK2798745
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated with congestive heart failure.
价 格:¥电议型 号:T15434产 地:中国大陆
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T15433GSK2795039;化合物GSK2795039GSK2795039
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
价 格:¥电议型 号:T15433产 地:中国大陆
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T15428Uprosertib hydrochloride;化合物 T15428GSK2141795 (hydrochloride);GSK2141795 (hydrochloride)
Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).
价 格:¥电议型 号:T15428产 地:中国大陆
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T15424GSK1379725A;化合物GSK1379725AGSK1379725A
GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).
价 格:¥电议型 号:T15424产 地:中国大陆
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T15409GNF179;化合物GNF179GNF179
GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.
价 格:¥电议型 号:T15409产 地:中国大陆
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T15368LGalantide acetate;化合物Galantide醋酸盐Galantide acetate(138579-66-5 Free base);Galantide acetate(138579-6
Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in the rat hypothalamus. Galantide acetate dose dependently (IC50=1.0 nM) antagonizes the galanin-mediated inhibition of the glucose-induced insulin secretion from mouse pancreatic islets. Galantide acetate appears to bind to a single population of SP receptors (KD~40 nM).
价 格:¥电议型 号:T15368L产 地:中国大陆
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T15342Fosravuconazole;化合物 T15342E-1224|||BMS-379224;E-1224|||BMS-379224
Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.
价 格:¥电议型 号:T15342产 地:中国大陆
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T15241ER-000444793;化合物ER-000444793ER-000444793
ER-000444793 is a potent mitochondrial permeability transition pore (mPTP) opening inhibitor and it also inhibits mPTP (IC50: 2.8 μM).
价 格:¥电议型 号:T15241产 地:中国大陆
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T15179DTSSP Crosslinker;化合物DTSSP CrosslinkerDTSSP Crosslinker
DTSSP Crosslinker is a cleavable ADC linker and can be used to synthesize antibody-drug conjugates (ADCs).
价 格:¥电议型 号:T15179产 地:中国大陆
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T15165DPI-3290;化合物 T15165Org 41793;Org 41793
DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally acting agents.
价 格:¥电议型 号:T15165产 地:中国大陆
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T15135LDirect Black 38 free acid;化合物 T15135LNSC8679|||Ferristatin II;NSC8679|||Ferristatin II
Ferristatin II (Direct Black 38 free acid) is a polysulphonated dye and promotes the degradation of transferrin receptor-1 in vitro and in vivo.
价 格:¥电议型 号:T15135L产 地:中国大陆
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T15079DBPR108;化合物DBPR108DBPR108
DBPR108 is an orally bioavailable dipeptide-derived DPP4 inhibitor (IC50: 15 nM) and it has no inhibition on DDP8 and DPP9.
价 格:¥电议型 号:T15079产 地:中国大陆