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T3977LLifitegrast sodium化合物 T3977LSAR-1118-023|||SAR1118-023|||SAR 1118-023|||Xiidra
Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus reducing overall inflammatory responses.
价 格:¥电议型 号:T3977L产 地:中国大陆
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T3977Lifitegrast;立他司特SHP-606|||SAR 1118;SHP-606|||SAR 1118|||立他司特|||利非司特
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
价 格:¥电议型 号:T3977产 地:中国大陆
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T39056AtuzabrutinibAtuzabrutinibSAR 444727|||PRN473
Atuzabrutinib is a potent BTK (Bruton´s tyrosine kinase) inhibitor.
价 格:¥电议型 号:T39056产 地:中国大陆
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T39031Olmesartan impurity;Olmesartan impurityOlmesartan impurity
Olmesartan impurity, a compound related to Olmesartan, is an angiotensin II receptor (AT1R) antagonist utilized in the study of high blood pressure. Olmesartan (RNH-6270) is the parent compound with similar properties and functions as an AT1R antagonist.
价 格:¥电议型 号:T39031产 地:中国大陆
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T39023Biotin-sar-oh;Biotin-sar-ohBiotin sar oh|||Biotinsaroh|||Biotin-sar-oh;Biotin sar oh|||Biotinsaroh||
Biotin-sar-oh is a cleavable linker vital in ADC synthesis. Biotin-sar-oh joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.
价 格:¥电议型 号:T39023产 地:中国大陆
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T38986Fitusiran;FitusiranALN-AT3SC|||SAR439774;ALN-AT3SC|||SAR439774
Fitusiran (ALN-AT3SC) is a small interfering RNA compound designed to selectively bind to antithrombin (AT) messenger RNA in the liver, leading to decreased AT production. By doing so, Fitusiran enhances thrombin generation, making it a promising candidate for hemophilia research.
价 格:¥电议型 号:T38986产 地:中国大陆
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T38951Isatuximab;艾萨妥昔单抗SAR-650984|||hu38SB19|||Isatuximab-irfc;SAR-650984|||hu38SB19|||Isatuximab-irfc
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and extracellular enzyme CD38 in malignant cells of the hematological system and is a highly expressed protein in multiple myeloma. Isatuximab has antitumor activity, antibody-dependent cytotoxicity, complement-dependent cytotoxicity, and antibody-dependent cytophagocytosis, which can directly induce apoptosis in the absence of crosslinking. Isatuximab has an inhibitory effect on CD38 extracellular enzyme activity, which is
价 格:¥电议型 号:T38951产 地:中国大陆
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T3887Rosarin;洛塞琳Rosarin
Rosarin has anti-inflammatory and neuroprotective effects. Rosarin supresses the expression of the proinflammatory factors iNOS, IL-1 β, and TNF- α in the kidney and prefrontal cortex of brain in mice .
价 格:¥电议型 号:T3887产 地:中国大陆
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T38829Lademirsen;LademirsenRG-012|||SAR339375;RG-012|||SAR339375
Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21 . Lademirsen has the potential for Alport nephropathy research.
价 格:¥电议型 号:T38829产 地:中国大陆
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T38716SAR247799;SAR247799SAR247799|||S1P1 agonist 3;SAR247799|||S1P1 agonist 3
SAR247799 (S1P1 agonist 3) is an orally-active, selective G-protein-biased agonist for the sphingosine-1 phosphate receptor-1 (S1P1). It demonstrates EC50 values ranging from 12.6 to 493 nM in S1P1-overexpressing cells and HUVECs. SAR247799 holds promise as a valuable tool for investigating endothelial protection, particularly in the context of type-2 diabetes and metabolic syndrome[4].
价 格:¥电议型 号:T38716产 地:中国大陆
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T3765L-asarinin;細辛素(-)-Episesamin;細辛素|||(-)-Episesamin
L-asarinin ((-)-Episesamin) reduces peripheral blood concentration of IL-12 and inhibits the expression of CXCR3 and TLR4, which means Asarinin may have a role on the TLR4 pathway and produce prolongation of allograft heart survival.
价 格:¥电议型 号:T3765产 地:中国大陆
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T37585Ensartinib;Ensartinib (X-396)Ensartinib
Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
价 格:¥电议型 号:T37585产 地:中国大陆
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T37174SARS-CoV MPro-IN-1MPro Inhibitor 11bSARSCoV MProIN1|||SARS CoV MPro IN 1
MProinhibitor 11b is an inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (MPro; IC50= 0.04 μM in a TR-FRET assay).1It reduces viral yield in the culture supernatant of SARS-CoV-2-infected Vero E6 cells (EC50= 0.72 μM). MProinhibitor 11b also reduces viral RNA copy numbers in the same model when used at concentrations ranging from 1.85 to 50 μM.
价 格:¥电议型 号:T37174产 地:中国大陆
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T3698alpha-Asaroneα-细辛脑α-Asarone|||trans-Asarone|||α-细辛脑
alpha-Asarone (trans-Asarone) is a psychoactive compound with antidepressant-like activity in mice.
价 格:¥电议型 号:T3698产 地:中国大陆
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T36950Rubrofusarin triglucoside;红镰霉素三葡萄糖苷Rubrofusarin triglucoside
Rubrofusarin triglucoside, a glycoside isolated from Cassia obtusifolia Linn seeds, demonstrates inhibitory activity against human monoamine oxidase A (hMAO-A), exhibiting an IC50 value of 85.5 μM[1].
价 格:¥电议型 号:T36950产 地:中国大陆
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T3691(Rac)-SAR131675;化合物SAR131675SAR131675;SAR131675
(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50: 20 nmol/L) and VEGFR-3 autophosphorylation (IC50: 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.
价 格:¥电议型 号:T3691产 地:中国大陆
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T36875Sartorypyrone D;Sartorypyrone DSartorypyrone D
Sartorypyrone D is a fungal metabolite that has been found inN. fischeri.1It inhibits NADH fumarate reductase (NFRD; IC50= 1.7 μM inA. suummitochondria) and NADH oxidase (IC50= 3 μM in bovine heart mitochondria). Sartorypyrone is active against the Gram-positive bacteriaB. subtilis,K. rhizophila, andM. smegmatisin disc assays.
价 格:¥电议型 号:T36875产 地:中国大陆
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T36654Anti-SARS-CoV-2 Spike mAb (CR3022);Anti-SARS-CoV-2 Spike mAb (CR3022)Anti-SARS-CoV-2 Spike mAb (CR30
Anti-SARS-CoV-2 Spike mAb (CR3022) is a human monoclonal IgG1 antibody derived from CHO cells. It specifically targets the S1 domain of the Spike protein in both SARS-CoV and SARS-CoV-2.
价 格:¥电议型 号:T36654产 地:中国大陆
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T36653Anti-SARS-80R mAb;Anti-SARS-80R mAbAnti-SARS-80R mAb
Anti-SARS-80R mAb (SARS-80R) is a human IgG1 monoclonal antibody that is derived from CHO cells. Its main function is to selectively bind to the Spike (S1) protein, effectively preventing the infection of susceptible cells by the SARS virus[1].
价 格:¥电议型 号:T36653产 地:中国大陆
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T36414N-Nitroso SarcosineN-Nitroso SarcosineNNitroso Sarcosine|||N Nitroso Sarcosine
N-Nitroso sarcosine is a carcinogen and nitrosation product of sarcosine that has been found in cured meat products.1,2
价 格:¥电议型 号:T36414产 地:中国大陆