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T9014SKI-178resistant,SphK,cytotoxic,myeloid,Inhibitor,Apoptosis,leukemia,multi-drug,inhibit,SKI-178,canc
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
价 格：￥电议型 号：T9014产 地：中国大陆
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T9027CA-4948rheumatoid,inflammation,CD135,inhibit,IL-1R associated kinase,CA4948,lymphoma,Interleukin-1 r
Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
价 格：￥电议型 号：T9027产 地：中国大陆
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T4050GSK2981278ROR gama modulator 1
GSK2981278 is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).
价 格：￥电议型 号：T4050产 地：中国大陆
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T39615LP8RI acetate
P8RI acetate is a biomimetic peptide of CD31 and an agonist of CDP8RI acetate shows an immunosuppressive effect through the restoration of the CD31 inhibitory pathway.
价 格：￥电议型 号：T39615L产 地：中国大陆
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T21468CVT-2738RS-94287；UNII-NYS3I6283H；CVT2738；CVT 2738；EC 610-916-8；N-(2,6-二甲基苯基)-1-哌嗪乙酰胺
CVT-2738 is a metabolite of Ranolazine. Ranolazine is a partial fatty acid oxidation (pFOX) inhibitor and anti-anginal drug.
价 格：￥电议型 号：T21468产 地：中国大陆
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T2007RQ-00203078RQ00203078
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
价 格：￥电议型 号：T2007产 地：中国大陆
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T0012Cinchonine奎宁树；辛可宁；(8R,9S)-Cinchonine；LA40221
Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
价 格：￥电议型 号：T0012产 地：中国大陆
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T0012CinchonineCinchonine,LA40221,(8R,9S)-Cinchonine
Cinchonine, a local anesthetic of the amide type, now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local narcotics and its parenteral use is restricted to spinal anesthesia.
价 格：￥电议型 号：T0012产 地：美洲
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T10564(8R,9S)-Talazoparib(8R,9S)-Talazoparib,(8R,9S)-BMN-673,
(8R,9S)-Talazoparib is Talazoparib enantiomer , less active than Talazoparib on the inhibition of PARP1 (IC50: 144 nM).
价 格：￥电议型 号：T10564产 地：美洲
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T16764RN-18RN-18
RN-18 is an HIV-1 viral infectivity factor inhibitor (IC50: 6 μM in nonpermissive H9 cells).
价 格：￥电议型 号：T16764产 地：美洲
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T16772Ro 64-6198Ro 64-6198
Ro 64-6198 is a nonpeptide, high-affinity, and brain penetration N/OFQ receptor (NOP) agonist (EC50: 25.6 nM). Ro 64-6198 is at least 100 times more selective for the NOP receptor over the classic opioid receptors.
价 格：￥电议型 号：T16772产 地：美洲
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T1896Ro 61-8048Ro 61-8048
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.
价 格：￥电议型 号：T1896产 地：美洲
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T2007RQ00203078RQ00203078
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist.
价 格：￥电议型 号：T2007产 地：美洲
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T2038RG108RG108,N-Phthalyl-L-tryptophan,
RG108 is an DNA methyltransferase inhibitor(IC50=115 nM).
价 格：￥电议型 号：T2038产 地：美洲
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T83517(Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-Tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahyd
Compound 7a, (Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate, is a clerodane diterpene [1].
价 格：￥电议型 号：T83517产 地：中国大陆
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T81264RLY-2608；化合物 RLY-2608RLY-2608
RLY-2608 is a pioneering, mutant-selective allosteric inhibitor of class IA PI3Kα (phosphoinositide 3-kinase alpha) [1].
价 格：￥电议型 号：T81264产 地：中国大陆
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T81239RXFP1 receptor agonist-8；化合物 RXFP1 receptor agonist-8RXFP1 receptor agonist-8
Example 2 (RXFP1 receptor agonist-8) is a potent RXFP1 receptor agonist that suppresses cAMP production in HEK293 cells expressing human RXFP1, exhibiting an EC50 of 1.8 nM [1].
价 格：￥电议型 号：T81239产 地：中国大陆
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T79870RMC-4998；化合物 RMC-4998RMC-4998
RMC-4998 is a molecular glue compound exhibiting potent antitumor activity, capable of forming a ternary complex with CYPA and an activated KRAS G12C mutation. Binding of CYPA to KRAS G12C impedes the interaction between activated KRAS mutants and downstream effector proteins, thus obstructing proliferative cell signaling [1].
价 格：￥电议型 号：T79870产 地：中国大陆
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T79809ROCK-IN-8；化合物 ROCK-IN-8ROCK-IN-8
ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrating an IC50 value below 100 nM [1].
价 格：￥电议型 号：T79809产 地：中国大陆
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T79605RIP1 kinase inhibitor 8；化合物 RIP1 kinase inhibitor 8RIP1 kinase inhibitor 8
RIP1 Kinase Inhibitor 8 (Compound 77), a potent and highly selective dihydropyrazole (DHP) RIP1 kinase inhibitor, exhibits an IC50 of 20 nM and effectively prevents necrotic cell death. It also demonstrates a favorable pharmacokinetic profile across multiple species [1].
价 格：￥电议型 号：T79605产 地：中国大陆
