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T77450Vantictumab;化合物 vantictumabOMP-18R5;OMP-18R5
Vantictumab (OMP-18R5), a fully human IgG2 monoclonal antibody, antagonizes Wnt pathway signaling through binding to FZD1/2/5/7/8 receptors. It is currently under investigation for the treatment of various cancers, including metastatic HER2-negative breast cancer and metastatic pancreatic adenocarcinoma [1] [2].
价 格:¥电议型 号:T77450产 地:中国大陆
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T75651Rivulariapeptolides 988;化合物 Rivulariapeptolides 988Rivulariapeptolides 988
Rivulariapeptolides 988 demonstrates significant potency and selectivity as a serine protease inhibitor, exhibiting IC50 values of 95.46 nM for chymotrypsin, 15.29 nM for elastase, and 85.50 nM for proteinase K [1].
价 格:¥电议型 号:T75651产 地:中国大陆
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T75223RDR 02308;化合物 RDR 02308RDR 02308
RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .
价 格:¥电议型 号:T75223产 地:中国大陆
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T74833EGFR T790M/L858R-IN-2;化合物 EGFR T790M/L858R-IN-2EGFR T790M/L858R-IN-2
EGFRT790M/L858R-IN-2 is a potent, selective inhibitor of EGFRT790M/L858R, exhibiting IC50 values of 3.5 nM for EGFRT790M/L858R and 1290 nM for EGFR WT. This compound effectively decreases the expression of p-EGFR, P-AKT, P-ERK1/2, and induces apoptosis as well as cell cycle arrest in the G1 phase, demonstrating anti-cancer activity [1].
价 格:¥电议型 号:T74833产 地:中国大陆
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T73480RMG8-8;化合物 RMG8-8RMG8-8
RMG8-8 shows the excellent efficacy against C. neoformans (1.56 μg/mL).
价 格:¥电议型 号:T73480产 地:中国大陆
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T73361RP101988;化合物 RP101988RP101988
RP101988, the principal active metabolite of Ozanimod, is a potent and selective agonist for sphingosine-1-phosphate receptor 1 (S1PR1), exhibiting half-maximal effective concentrations (EC50s) of 0.19 nM for S1PR1 and 32.8 nM for S1PR5.
价 格:¥电议型 号:T73361产 地:中国大陆
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T73196RGB-286638;化合物 RGB-286638RGB-286638
RGB-286638 is a multi-target CDK inhibitor that effectively hampers the kinase activity of a range of cyclin-CDK complexes, including cyclin T1-CDK9 (IC50 = 1 nM), cyclin B1-CDK1 (IC50 = 2 nM), cyclin E-CDK2 (IC50 = 3 nM), cyclin D1-CDK4 (IC50 = 4 nM), cyclin E-CDK3 (IC50 = 5 nM), and p35-CDK5 (IC50 = 5 nM). Additionally, it inhibits other kinases such as GSK-3β (IC50 = 3 nM), TAK1 (IC50 = 5 nM), Jak2 (IC50 = 50 nM), and MEK1 (IC50 = 54 nM), showcasing its versatile inhibitory potential.
价 格:¥电议型 号:T73196产 地:中国大陆
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T71819RK-20448;化合物 RK-20448RK-20448
RK-20448 is an ATP-competitive inhibitor of Lck, Src, KDR/VEGF2R, and Tie-2. It also inhibits BLK, Csk, Fyn, and Lyn. RK-20448 is the cis isomer of A-419259
价 格:¥电议型 号:T71819产 地:中国大陆
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T71748RK-0404678;化合物 RK-0404678RK-0404678
RK-0404678 is a novel inhibitor of dengue virus NS5 RNA-dependent RNA polymerase (RdRp), inhibiting the DENV type 2 (DENV2) RdRp activities.
价 格:¥电议型 号:T71748产 地:中国大陆
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T71457RGH-618;化合物 RGH-618RGH-618
RGH-618 is an agonist of metabotropic glutamate receptor types 1 and 5, for the treatment of anxiety disorders.
价 格:¥电议型 号:T71457产 地:中国大陆
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T695398RK64;化合物 8RK648RK64
8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) [1] .
价 格:¥电议型 号:T69539产 地:中国大陆
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T68623RO4583298;化合物 RO4583298RO4583298
RO4583298 is a highly potent dual NK1/NK3 receptor antagonist with in vivo activity.
价 格:¥电议型 号:T68623产 地:中国大陆
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T68051LRS 15385-198;化合物RS 15385-198RS 15385-198
RS 15385-198 is a less active isomer of Delequamine. Delequamine is a selective alpha2-adrenergic receptor antagonist.
价 格:¥电议型 号:T68051L产 地:中国大陆
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T67388N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]triox
N-(1-((6aR,8R,9aR)-9-Cyano-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide is a useful organic compound for research related to life sciences and the catalog number is T67388.
价 格:¥电议型 号:T67388产 地:中国大陆
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T66656(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopent
(R)-Methyl 4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66656 and the CAS number is 10538-59-7.
价 格:¥电议型 号:T66656产 地:中国大陆
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T6634RBC8;化合物RBC8RBC8
RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.
价 格:¥电议型 号:T6634产 地:中国大陆
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T66315(7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta
(7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol is a useful organic compound for research related to life sciences. The catalog number is T66315 and the CAS number is 875573-67-4.
价 格:¥电议型 号:T66315产 地:中国大陆
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T66301(3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopent
(3S,8R,9S,10R,13S,14S)-17-Iodo-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol is a useful organic compound for research related to life sciences. The catalog number is T66301 and the CAS number is 32138-69-5.
价 格:¥电议型 号:T66301产 地:中国大陆
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T66136(R)-Methyl 4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-
(R)-Methyl 4-((3R,5S,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate is a useful organic compound for research related to life sciences. The catalog number is T66136 and the CAS number is 10538-65-5.
价 格:¥电议型 号:T66136产 地:中国大陆