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  • T4028ML329；化合物ML329ML329

    ML329 is a small molecule inhibitor of MITF, inhibiting TRPM-1 promoter activity.

    价 格：￥电议型 号：T4028产 地：中国大陆

  • T3961CYM-5541；化合物CYM 5541CYM 5541|||ML249|||CID-17253208；CYM 5541|||ML249|||CID-17253208

    CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist.

    价 格：￥电议型 号：T3961产 地：中国大陆

  • T39295RemlarsenRemlarsenMRG-201

    Remlarsen (MRG-201), a miR-29b mimic, functions as a miR-29b agonist with the potential to prevent the formation of fibrotic scars or cutaneous fibrosis.

    价 格：￥电议型 号：T39295产 地：中国大陆

  • T39287Ledaborbactam；LedaborbactamLedaborbactam

    Iedaborbactam, as a beta-lactamase inhibitor (WO2015191907, Example 62), can be used for the research of bacterial infections.

    价 格：￥电议型 号：T39287产 地：中国大陆

  • T39274Lumasiran sodium；Lumasiran sodiumLumasiran sodium

    Lumasiran sodium, an investigational RNA interference (RNAi) therapeutic agent, targets glycolate oxidase to reduce hepatic oxalate production, thereby reducing urinary oxalate excretion. This compound shows promise in addressing the underlying cause of progressive kidney failure in individuals with primary hyperoxaluria type 1 (PH1).

    价 格：￥电议型 号：T39274产 地：中国大陆

  • T39271MLT-985；MLT-985MLT-985

    MLT-985 is a highly selective allosteric MALT1 inhibitor with an IC 50 value of 3 nM.

    价 格：￥电议型 号：T39271产 地：中国大陆

  • T39199ML 120B dihydrochlorideML 120B dihydrochlorideML120B dihydrochloride

    MLN120B dihydrochloride (ML120B dihydrochloride) is a highly potent, orally active inhibitor of IKKβ. It competitively binds to ATP and exhibits an impressive IC50 value of 60 nM. This compound effectively suppresses the growth of multiple myeloma cells both in vitro and in vivo. Furthermore, MLN120B dihydrochloride is valuable in the field of rheumatoid arthritis research.

    价 格：￥电议型 号：T39199产 地：中国大陆

  • T39109ML338ML338ML338

    ML338 is a selective small molecule inhibitor probe specifically targeting non-replicating Mycobacterium tuberculosis bacilli. It exhibits potent activity against non-replicating M. tuberculosis, with IC90 and IC99 values of 1 μM and 4 μM, respectively, as determined by CFU. This compound, ML338, is an invaluable tool for identifying essential functions and vulnerabilities of M. tuberculosis bacilli under nutrient deprivation conditions. Additionally, ML338 is highly useful for studying M. tuber

    价 格：￥电议型 号：T39109产 地：中国大陆

  • T39102MLK-IN-1；MLK-IN-1MLK-IN-1

    MLK-IN-1 (US20140256733A1, compound 68) is a highly potent and selective inhibitor of mixed lineage kinase 3 (MLK-3). It exhibits excellent brain penetration and specifically targets MLK-3.

    价 格：￥电议型 号：T39102产 地：中国大陆

  • T38998Pramlintide；普兰林肽Pramlintide

    Pramlintide, a polypeptide analog of human amylin, is an antidiabetic agent with antineoplastic properties in colorectal cancer.

    价 格：￥电议型 号：T38998产 地：中国大陆

  • T38428Alisertib sodium；Alisertib sodiumMLN 8237 sodium；MLN 8237 sodium

    Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle and causes abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells. This compound exhibits significant antitumor activity.

    价 格：￥电议型 号：T38428产 地：中国大陆

  • T38163ML-148；化合物ML-148ML-148

    ML-148 is a selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH, IC50 = 56 nM). ML-148 can be used to profile across a panel of related dehydrogenase or reductase enzymes and in studies about prostaglandin-signaling pathways.

    价 格：￥电议型 号：T38163产 地：中国大陆

  • T38096MLT-231；MLT-231MLT-231

    MLT-231, a potent and highly selective allosteric MALT1 inhibitor, has an IC50 of 9 nM and specifically inhibits endogenous BCL10 cleavage with an IC50 of 160 nM. It exhibits antitumor activity in an ABC-DLBCL type xenograft mouse model[1].

    价 格：￥电议型 号：T38096产 地：中国大陆

  • T37590ML 3403；ML 3403ML 3403

    p38 MAPK inhibitor (IC50 = 0.38 μM). Inhibits the release of IL-1β and TNF-α in a peripheral blood mononuclear cell (PBMC) assay (IC50 values are 0.039 and 0.16 μM respectively).

    价 格：￥电议型 号：T37590产 地：中国大陆

  • T37587ML 209；化合物(±)-ML 209ML 209

    ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells.

    价 格：￥电议型 号：T37587产 地：中国大陆

  • T37148TML-6；TML-6TML-6

    TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, and enhancement of the anti-oxidative Nrf2 gene activity. Considering its diverse pharmacological profile, TML-6 holds promise as a valuable research tool for investigating Alzheimer´s disease (AD)[1].

    价 格：￥电议型 号：T37148产 地：中国大陆

  • T36964BML-259；化合物BML-259CAY10554；CAY10554

    BML-259 is an inhibitor of CDK5 and CDK2 with IC50s of 64 and 98 nM, respectively. BML-259 can be used in studies about the treatment of cancer and neurodegenerative diseases.

    价 格：￥电议型 号：T36964产 地：中国大陆

  • T36911Pramlintide (acetate hydrate)；Pramlintide (acetate hydrate)Pramlintide (acetate hydrate)

    Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner.

    价 格：￥电议型 号：T36911产 地：中国大陆

  • T36721Dehydro Amlodipine (fumarate)；Dehydro Amlodipine (fumarate)Dehydro Amlodipine (fumarate)

    Dehydro amlodipine is a potential impurity found in commercial preparations of amlodipine. It is a degradation product formed during storage or when amlodipine is subjected to oxidative or acidic conditions or undergoes photo or electrochemical degradation.

    价 格：￥电议型 号：T36721产 地：中国大陆

  • T36707ML 315；化合物 ML 315ML 315

    ML 315 is a selective Clk and DYRK inhibitor with potential anticancer activity for the study of neurological disorders.

    价 格：￥电议型 号：T36707产 地：中国大陆

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