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  • T16511PF2562；化合物 T16511PF2562

    PF2562 is a dopamine D1 ligand. It is used as a dopamine D1 agonist or partial agonist. PF2562 binds to human D1 receptor (Ki: 113 nM). PF2562 shows activity against human D1 cAMP (EC50: 568 nM in HTRF assay).

    价 格：￥电议型 号：T16511产 地：中国大陆

  • T16510PF-915275；化合物PF-915275PF-915275

    PF-915275 is an effective and selective inhibitor of human 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1, Ki = 2.3 nM, EC50 = 15 nM in vitro HEK293 cells). The dose-dependent effect of PF-915275 on conversion of cortisone to cortisol in primary human and monkey hepatocytes, with an EC50 of 20 and 100 nM, respectively.

    价 格：￥电议型 号：T16510产 地：中国大陆

  • T1651Rabeprazole sodium；雷贝拉唑钠Dexrabeprazole Sodium|||LY307640 sodium|||Habeprazole Sodium|||Rebeprazole s

    Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exchanging ATPase which is found in gastric parietal cells.

    价 格：￥电议型 号：T1651产 地：中国大陆

  • T16508PF-5190457；化合物PF-5190457PF-05190457；PF-05190457

    PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).

    价 格：￥电议型 号：T16508产 地：中国大陆

  • T16507PF-5006739；化合物 T16507PF-5006739

    PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent m

    价 格：￥电议型 号：T16507产 地：中国大陆

  • T16506PF-4878691；化合物PF-48786913M-852A；3M-852A

    PF-4878691 (3M-852A) is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.

    价 格：￥电议型 号：T16506产 地：中国大陆

  • T16505PF-4778574；化合物 T16505PF-4778574

    PF-4778574 is a positive AMPA receptor allosteric modulation (EC50: 45 to 919 nM in different cells).

    价 格：￥电议型 号：T16505产 地：中国大陆

  • T16504PF-4693627；化合物 T16504PF-4693627

    PF-4693627 is an effective and selective microsomal prostaglandin E synthase-1 inhibitor (IC50=3 nM). It is used for the treatment of inflammation caused by osteoarthritis (OA) and rheumatoid arthritis (RA).

    价 格：￥电议型 号：T16504产 地：中国大陆

  • T16503PF-4191834；化合物PF-4191834PF-04191834；PF-04191834

    PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 of 229 nM. PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-4191834

    价 格：￥电议型 号：T16503产 地：中国大陆

  • T16502PF-3882845；化合物 T16502PF-3882845

    PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy.

    价 格：￥电议型 号：T16502产 地：中国大陆

  • T16501PF-3644022；化合物PF-3644022PF-3644022

    PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) (IC50s: 53 nM and 5.0 nM, respectively).

    价 格：￥电议型 号：T16501产 地：中国大陆

  • T16500PF-3450074；化合物PF-3450074PF-74；PF-74

    PF-3450074 (PF-74) acts at an early stage of HIV-1 infection inhibits viral replication by directly competing with the binding of CPSF6 (nuclear host factors cleavage and polyadenylation specific factor 6) and NUP153 (nucleoporin 153), and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle. PF-3450074 is a specifical inhibitor of?HIV-1 capsid protein (CA) and shows a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM).

    价 格：￥电议型 号：T16500产 地：中国大陆

  • T1650Chlorzoxazone；氯唑沙宗Paraflex|||Chlorzoxazon；Paraflex|||Chlorzoxazon|||氯唑沙宗

    Chlorzoxazone (Chlorzoxazon) is a Muscle Relaxant. The physiologic effect of chlorzoxazone is by means of Centrally-mediated Muscle Relaxation.

    价 格：￥电议型 号：T1650产 地：中国大陆

  • T16346NS1652；化合物NS1652NS1652

    NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.

    价 格：￥电议型 号：T16346产 地：中国大陆

  • T16165Myriocin多球壳菌素ISP-I|||Thermozymocidin

    Myriocin (Thermozymocidin), a metabolite derived from Myriococcum albomyces, is a serine-palmitoyltransferase (SPT) inhibitor with potential antitumour, anticancer, and antiparasitic activities.Myriocin inhibits tumour growth by regulating macrophage polarisation and function through the PI3K/Akt/mTOR pathway.Myriocin inhibits HCV infection and can be used in the study of neurological diseases. Myriocin inhibits HCV infection and can be used to study neuropathy and fungal infections.

    价 格：￥电议型 号：T16165产 地：中国大陆

  • T15812LY2979165；化合物LY2979165mGlu2 agonist；mGlu2 agonist

    LY2979165 (mGlu2 agonist) is an orthosteric agonist of mGluR2 and can be used in studies about serving as an anti-depressant.

    价 格：￥电议型 号：T15812产 地：中国大陆

  • T15808Merestinib dihydrochloride化合物 T15808LY2801653 dihydrochloride

    Merestinib dihydrochloride is an effective and orally bioavailable c-Met inhibitor (Ki=2 nM). It has anti-tumor activities and also has potent activity against MST1R (IC50=11 nM), FLT3 (IC50=7 nM), AXL (IC50=2 nM), MERTK (IC50=10 nM), TEK (IC50=63 nM), ROS1, DDR1/2 (IC50=0.1/7 nM) and MKNK1/2 (IC50=7 nM).

    价 格：￥电议型 号：T15808产 地：中国大陆

  • T15165DPI-3290；化合物 T15165Org 41793；Org 41793

    DPI-3290 is a specific agonist of opioid receptors (Ki: 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively) with potent antinociceptive activity. DPI-3290 is one of a series of novel centrally acting agents.

    价 格：￥电议型 号：T15165产 地：中国大陆

  • T14923Cefpiramide sodium头孢匹胺钠头孢匹胺钠|||SM-1652|||Wy-44635

    Cefpiramide sodium (SM-1652; Wy-44635) is a Pseudomonas-active cephalosporin. It has a broad spectrum of antibacterial activity.

    价 格：￥电议型 号：T14923产 地：中国大陆

  • T14687Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165

    Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.

    价 格：￥电议型 号：T14687产 地：中国大陆

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