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T1060Flumequine；氟甲喹Flumigal|||R-802；Flumigal|||氟甲喹|||R-802
Flumequine (R-802) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.
价 格：￥电议型 号：T1060产 地：中国大陆
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T10589LBPN-15606；化合物 T10589LBPN-15606
BPN-15606, an orally active γ-secretase modulator (GSM), significantly reduces Aβ42 and Aβ40 production in SHSY5Y neuroblastoma cells, demonstrating IC50 values of 7 nM and 17 nM, respectively. This compound exhibits favorable pharmacokinetic/pharmacodynamic (PK/PD) properties, such as bioavailability, half-life, and clearance. Importantly, BPN-15606 markedly decreases Aβ42 and Aβ40 levels in the central nervous system of both rats and mice[1].
价 格：￥电议型 号：T10589L产 地：中国大陆
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T10589BPN-15606 besylate (1914989-49-3 free base)；化合物 T10589BPN-15606 besylate；BPN-15606 besylate
BPN-15606 besylate is a highly potent, orally active γ-secretase modulator, attenuates the production of Aβ40 and Aβ42 by SHSY5Y neuroblastoma cells (IC50s: 7 nM and 17nM).
价 格：￥电议型 号：T10589产 地：中国大陆
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T10586LBPH-1358；化合物BPH-1358NSC50460；NSC50460
BPH-1358 (NSC-50460) (NSC-50460) is a potent human farnesyl diphosphate synthase (FPPS) and undecaprenyl diphosphate synthase (UPPS) inhibitor. With IC50s of 1.8 μM and 110 nM, respectively. And it is active against S. aureus in vitro (MIC ~250 ng/mL)[1][2].
价 格：￥电议型 号：T10586L产 地：中国大陆
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T10586BPH-1358 free base；化合物 T10586NSC50460 free base；NSC50460 free base
BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
价 格：￥电议型 号：T10586产 地：中国大陆
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T10560P2X3 antagonist 34；化合物 T10560BLU-5937；BLU-5937
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It shows reduced activity against P2X2/3 heterotrimeric receptors across human, rat, and guinea pig models. Notably, this compound demonstrates a significant anti-tussive effect without altering taste[1].
价 格：￥电议型 号：T10560产 地：中国大陆
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T10543BIIL-260 hydrochloride；化合物 T10543BIIL-260 hydrochloride
BIIL-260 hydrochloride is a potent and long-acting orally active antagonist of leukotriene B4 (LTB4) receptor with anti-inflammatory activity. It has a high affinity to the LTB4 receptor on isolated human neutrophil cell membranes (Ki: 1.7 nM).
价 格：￥电议型 号：T10543产 地：中国大陆
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T10471BAY 60-2770；化合物 T10471BAY 60-2770
BAY 60-2770 is a selective and orally active soluble guanylyl cyclase (sGC) activator with antifibrotic effect. It increases the activity of sGC in a nitric oxide-independent manner.
价 格：￥电议型 号：T10471产 地：中国大陆
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T10467BAY-1816032；化合物BAY-1816032BAY-1816032
BAY-1816032 is a potent and orally available inhibitor of bidding uninhibited by benzimidazoles 1 ( BUB1) kinase (IC50: 7 nM).
价 格：￥电议型 号：T10467产 地：中国大陆
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T10460Batabulin；巴他布林T138067；巴他布林|||T138067
Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to cell-cycle arrest ultimately induce apoptotic cell death.
价 格：￥电议型 号：T10460产 地：中国大陆
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T10426AZ12601011；化合物 T10426AZ12601011
AZ12601011 is a highly potent and selective inhibitor of the TGFBR1 kinase, administered orally. It displays an IC50 of 18 nM and a Kd of 2.9 nM. By selectively targeting ALK4, TGFBR1, and ALK7, AZ12601011 effectively inhibits the phosphorylation of SMAD2. Additionally, it has been shown to hinder the growth and metastasis of mammary tumors [1].
价 格：￥电议型 号：T10426产 地：中国大陆
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T10360AR-A 2；化合物 T10360AR-A 000002；AR-A 000002
AR-A 2 is a selective 5-HT1B receptor antagonist, with a high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki: 0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki: 5 nM).
价 格：￥电议型 号：T10360产 地：中国大陆
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T10343AOH1160；化合物AOH1160N-(2-Oxo-2-(2-phenoxyphenylamino)ethyl)-1-naphthamide；N-(2-Oxo-2-(2-phenoxyphenyla
AOH1160 is an inhibitor of proliferating cell nuclear antigen (PCNA). AOH1160 induces apoptosis and causes cell-cycle arrest by interfering with DNA replication.
价 格：￥电议型 号：T10343产 地：中国大陆
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T10298L2AMG-548 dihydrochloride (864249-60-5 free base)；化合物 T10298L2AMG-548 dihydrochloride；AMG-548 dihydroc
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).
价 格：￥电议型 号：T10298L2产 地：中国大陆
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T10298AMG-548 hydrochloride (864249-60-5 free base)；化合物 T10298AMG-548 hydrochloride；AMG-548 hydrochloride
AMG-548 hydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).
价 格：￥电议型 号：T10298产 地：中国大陆
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T10282Aliskiren D6 Hydrochloride；化合物 T10282SPP 100 D6 Hydrochloride|||CGP60536B D6 Hydrochloride|||CGP 605
Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).
价 格：￥电议型 号：T10282产 地：中国大陆
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T10260Aglafoline；化合物 T10260Rocaglamide U|||Aglafolin|||(-)-Methyl rocaglate；Rocaglamide U|||Aglafolin|||(-
Aglafoline inhibits in a concentration-dependent manner the aggregation and ATP release reaction induced in washed rabbit platelets by PAF (platelet-activating factor). The IC50 values of Aglafoline on PAF (3.6 nM)-induced platelet aggregation were about 50 μM.
价 格：￥电议型 号：T10260产 地：中国大陆
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T1016011β-HSD1-IN-1；化合物11β-HSD1-IN-111β-HSD1-IN-1
11β-HSD1-IN-1 is an inhibitor of 11β-hydroxydehydrogenase 1 (11β-HSD1, IC50: 52 nM), and used for the treatment of pain.
价 格：￥电议型 号：T10160产 地：中国大陆
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T100886Compound 1080-0560；化合物 1080-0560Compound 1080-0560
Compound 1080-0560 is a useful organic compound for research related to life sciences and the catalog number is T100886.
价 格：￥电议型 号：T100886产 地：中国大陆
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T10060LDT-061；化合物 T10060LDT-061
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
价 格：￥电议型 号：T10060L产 地：中国大陆
