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T20994Amlodipine besilate impurity G；化合物 T20994Amlodipine besilate impurity G
Amlodipine besilate impurity G is a Calcium Channel antagonist with potential application in the study of neurological diseases and is an impurity in the synthesis of Amlodipine besilate.
价 格：￥电议型 号：T20994产 地：中国大陆
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T2033BML-277；化合物BML-277C 3742|||Chk2 Inhibitor II|||BML 277；C 3742|||Chk2 Inhibitor II|||BML 277
BML-277 (C 3742) is a selective checkpoint kinase 2 (Chk2) inhibitor.
价 格：￥电议型 号：T2033产 地：中国大陆
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T2016MLN9708；化合物Ixazomib CitrateIxazomib Citrate；Ixazomib Citrate
MLN2238 suppresses the chymotrypsin-like proteolytic (β5) site of the 20S proteasome(Ki50=0.93 nM, IC50=3.4 nM/). The biologically active form of MLN9708 (Ixazomib Citrate) is MLN2238 in aqueous solutions or plasma.
价 格：￥电议型 号：T2016产 地：中国大陆
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T1983CAY10603；化合物CAY10603HDAC6 Inhibitor|||BML-281；HDAC6 Inhibitor|||BML-281
CAY10603 (BML-281) is a potent and selective inhibitor of HDAC6.
价 格：￥电议型 号：T1983产 地：中国大陆
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T1977Dorsomorphin；化合物DorsomorphinCompound C|||BML-275；Compound C|||BML-275
Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive. Dorsomorphin inhibits the BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin induces autophagy, and possesses antitumor activity.
价 格：￥电议型 号：T1977产 地：中国大陆
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T1943ML347；化合物ML347LDN 193719；LDN 193719
ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.
价 格：￥电议型 号：T1943产 地：中国大陆
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T1893Parmodulin 2；化合物ML 161ML 161；ML 161
Parmodulin 2 (ML 161) is the inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50: 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). It also inhibits thrombin-induced platelet activation.
价 格：￥电议型 号：T1893产 地：中国大陆
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T1838Sapanisertib；沙帕色替TAK-228|||MLN0128|||INK 128；沙帕色替|||TAK-228|||MLN0128|||INK 128
Sapanisertib (INK 128) is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
价 格：￥电议型 号：T1838产 地：中国大陆
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T1757ML-323；化合物ML323ML323；ML323
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (IC50: 174 nM 820 nM)and monoubiquitinated PCNA (Ub-PCNA) (IC50: 820 nM) as substrates, respectively.
价 格：￥电议型 号：T1757产 地：中国大陆
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T16974TAK-243；化合物TAK-243MLN7243；MLN7243
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM). TAK-243 blocks ubiquitin binding and disrupts mono-ubiquitin signaling as well as overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.
价 格：￥电议型 号：T16974产 地：中国大陆
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T1667Tandutinib；坦度替尼MLN518|||CT53518|||NSC726292；MLN518|||CT53518|||NSC726292|||坦度替尼
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR, and KDR.
价 格：￥电议型 号：T1667产 地：中国大陆
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T1639Amlexanox；氨来呫诺CHX3673|||Amoxanox|||AA673；氨来呫诺|||CHX3673|||Amoxanox|||氨来诺|||AA673
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
价 格：￥电议型 号：T1639产 地：中国大陆
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T16120MLT-748；化合物 T16120MLT-748
MLT-748 is an effective, selective, and allosteric MALT1 inhibitor. It binds MALT1 in the allosteric Trp580 pocket (IC50: 5 nM).
价 格：￥电议型 号：T16120产 地：中国大陆
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T16119MLT-747；化合物 T16119MLT-747
MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).
价 格：￥电议型 号：T16119产 地：中国大陆
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T16118MLS0315771；化合物MLS0315771MLS0315771
MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).
价 格：￥电议型 号：T16118产 地：中国大陆
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T16117Pevonedistat hydrochloride化合物 T16117MLN4924 hydrochloride
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
价 格：￥电议型 号：T16117产 地：中国大陆
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T16116MLN-4760；化合物MLN-4760MLN-4760
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
价 格：￥电议型 号：T16116产 地：中国大陆
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T16115MLi-2；化合物MLi-2MLi-2
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
价 格：￥电议型 号：T16115产 地：中国大陆
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T16114Pavinetant；化合物 PavinetantMLE-4901|||AZD4901|||AZD2624；MLE-4901|||AZD4901|||AZD2624
Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms.
价 格：￥电议型 号：T16114产 地：中国大陆
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T16113ML753286；化合物 T16113ML753286
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.
价 格：￥电议型 号：T16113产 地：中国大陆
