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T36036CAY10786;化合物CAY10786GPR52 antagonist-1;GPR52 antagonist-1
CAY10786 (GPR52 antagonist-1) is an antagonist of G protein-coupled receptor 52 (GPR52, IC50 = 0.63 μM).
价 格:¥电议型 号:T36036产 地:中国大陆
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T35992ent-Prostaglandin F2α;ent-Prostaglandin F2αent-Prostaglandin F2α;ent-Prostaglandin F2α
ent-Prostaglandin F2α is the enantiomer of PGF2α and is found in urine.
价 格:¥电议型 号:T35992产 地:中国大陆
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T35991ent-Prostaglandin E2;ent-Prostaglandin E2ent-Prostaglandin E2;ent-Prostaglandin E2
Enzymatically-derived prostaglandin E2 (PGE2) is an optically pure compound whereas PGE2 derived from the free radical-catalyzed peroxidation of arachidonate is a racemic mixture. Ent-PGE2 is the opposite enantiomer of PGE2. Significant amounts of racemic PGE2 (rac-PGE2) are generated in vitro and in vivo in settings of oxidative stress via the isoprostane pathway. A proposed mechanism for the formation of rac-PGE2 involves the base catalyzed equilibration from 15-E2t-isoprostane (8-iso-PGE2), g
价 格:¥电议型 号:T35991产 地:中国大陆
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T35990ent-8-iso-15(S)-Prostaglandin F2α;ent-8-iso-15(S)-Prostaglandin F2αent-8-iso-15(S)-Prostaglandin F2α
Isoprostanes are produced by the non-enzymatic, free radical peroxidation of phospholipid-esterified arachidonic acid. They have been used as biomarkers of oxidative stress, but they also have been found to have potent biological activity. ent-8-iso-15(S)-Prostaglandin F2α (ent-8-iso-15(S)-PGF2α) is a potent vasoconstrictor of porcine retinal and brain microvessels with EC50 values of 15 and 24 nM, respectively. This isoprostane is about ten-fold more potent than 8-iso-PGF2α in a whole blood pla
价 格:¥电议型 号:T35990产 地:中国大陆
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T35961Prostaglandin Bx;Prostaglandin BxProstaglandin Bx
PGBx is a mixture of oligomers of PGB1 with a molecular weight of 1,000-1,500. It has antioxidant and free radical trapping activity that was first studied in isolated mitochondria.1 PGBx has anti-inflammatory and cytoprotective activity which may be attributed to inhibition of the 14 kDa sPLA2.2,3 At a dose of 1 mg/kg, PGBx significantly reduces the incidence of ulcers in rats.2
价 格:¥电议型 号:T35961产 地:中国大陆
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T3594415-keto-17-phenyl trinor Prostaglandin F2α ethyl amide;15-keto-17-phenyl trinor Prostaglandin F2α et
Bimatoprost is the Allergan trade name for 17-phenyl trinor prostaglandin F2α ethyl amide (17-phenyl trinor PGF2α ethyl amide), an F-series PG analog which has been approved for use as an ocular hypotensive drug. Oxidation of the C-15 hydroxyl group produces 15-keto-17-phenyl trinor PGF2α ethyl amide. 15-keto-17-phenyl trinor PGF2α ethyl amide is a potential metabolite of 17-phenyl trinor PGF2α ethyl amide when 17-phenyl trinor PGF2α ethyl amide is administered to intact animals. No pharmacologi
价 格:¥电议型 号:T35944产 地:中国大陆
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T35637Sitagliptin N-Sulfate (sodium salt);Sitagliptin N-Sulfate (sodium salt)Sitagliptin N-Sulfate (sodium
Sitagliptin N-sulfate is a phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . Sitagliptin N-sulfate is formed via sulfation and has been found in rat bile following oral administration of (-)-sitagliptin.
价 格:¥电议型 号:T35637产 地:中国大陆
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T35537Hedgehog Antagonist VIII;Hedgehog Antagonist VIIIHedgehog Antagonist VIII
Hedgehog (Hh) proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. Hh antagonist VIII is a cell-permeable quinazolinyl-urea compound that has been shown to inhibit Gli transcription activity
价 格:¥电议型 号:T35537产 地:中国大陆
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T35475aTAG 4531;aTAG 4531aTAG 4531
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.34 nM; Dmax = 93.14%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genom
价 格:¥电议型 号:T35475产 地:中国大陆
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T35474aTAG 2139;aTAG 2139aTAG 2139
Degrader of MTH1 fusion proteins for use within the aTAG system. Comprises a ligand selective for MTH1, a linker and the cereblon-binding ligand Thalidomide . Induces highly potent and selective degradation of fusion proteins after a 4 h incubation (DC50 = 0.27 nM; Dmax = 92.1%). Cell-permeable. Suitable for in vitro and in vivo applications. Mouse DMPK properties are provided in the supplementary file (see below). (MTH1 can be expressed as a fusion with a target protein of interest using genome
价 格:¥电议型 号:T35474产 地:中国大陆
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T3547Sotagliflozin;化合物SotagliflozinLX-4211|||LP-802034;LX-4211|||LP-802034
Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
价 格:¥电议型 号:T3547产 地:中国大陆
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T35440(-)-Sitagliptin Carbamoyl Glucuronide;(-)-Sitagliptin Carbamoyl Glucuronide(-)-Sitagliptin Carbamoyl
(-)-Sitagliptin carbamoyl glucuronide is a minor phase II metabolite of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin . (-)-Sitagliptin carbamoyl glucuronide is formed by N-carbamoyl glucuronidation and has been found in rat and dog plasma following administration of (-)-sitagliptin.
价 格:¥电议型 号:T35440产 地:中国大陆
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T34772Tagorizine;化合物 T34772AL-3264|||AL3264|||AL 3264;AL-3264|||AL3264|||AL 3264
Tagorizine is a biochemical.
价 格:¥电议型 号:T34772产 地:中国大陆
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T34771Taglutimide;化合物 T34771Taglutimide
Taglutimide is a sedative-hypnotic derivative of glutarimide.
价 格:¥电议型 号:T34771产 地:中国大陆
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T34770Tagatose;化合物 T34770Tagatose
Tagatose is a sweetener based on its properties as a monosaccharide, specifically a hexose.
价 格:¥电议型 号:T34770产 地:中国大陆
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T3460HhAntag;化合物HhAntagHhAntag
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity.
价 格:¥电议型 号:T3460产 地:中国大陆
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T3450LX4211 N-4 Intermediate 9化合物 T3450索格列净中间体9|||Sotagliflozin Intermediate 9
LX4211 N-4 Intermediate 9 is an intermediate of Sotagliflozin, which is an orally bioavailable inhibitor of SGLT1 and SGLT2.
价 格:¥电议型 号:T3450产 地:中国大陆
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T34183Pteroylpentaglutamic acid;化合物 T34183Pte-penta-glu|||NSC372667|||NSC 372667|||NSC-372667;Pte-penta-gl
Pteroylpentaglutamic acid within the folic acid family is a bioactive chemical.
价 格:¥电议型 号:T34183产 地:中国大陆
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T33916Pentagastrin meglumine;化合物 T33916Pentagastrin meglumine
Pentagastrin meglumine is a synthetic pentapeptide that has effects like gastrin when given parenterally.
价 格:¥电议型 号:T33916产 地:中国大陆
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T31503Dinoprost methoxyamine;化合物 T31503l-Prostaglandin F2-alpha methoxamine salt|||l-PGF2-alpha methoxamin
Dinoprost methoxyamine is a hormone.
价 格:¥电议型 号:T31503产 地:中国大陆